Journal article
Optical density filters modeling media opacities cause decreased SD-OCT retinal layer thickness measurements with inter- and intra-individual variation
Acta ophthalmologica, Vol.93(4), pp.355-361
06/2015
DOI: 10.1111/aos.12596
PMID: 25487761
Abstract
To assess the effect of media opacities on thickness measurements of the peripapillary retinal nerve fibre layer (pRNFL) and macular inner retinal layer (mIRL) performed with spectral-domain optical coherence tomography (SD-OCT) using a set of filters with known optical density. Spectral-domain optical coherence tomography volume scans of the optic disc and the macular area were performed in 18 healthy volunteers, using Topcon-3DOCT-1000 Mark II. A set of five filters with optical density ranging from 0.04 to 0.69 was used. The correlation was calculated between the percentage change in thickness measurements (%ΔpRNFL and %ΔmIRL) and the change in optical density. All scans and measurements were performed in duplicate by one operator. Eighteen right eyes of 18 healthy volunteers were included in this study. Percentage decrease in pRNFL and mIRL thickness correlated with change in optical density (Spearman's rho r = 0.82; p < 0.001 and r = 0.89; p < 0.001, respectively). The measured decrease in pRNFL thickness differed from the decrease in mIRL thickness, not only between individuals, but also within the same individual. Optical coherence tomography thickness measurements of both pRNFL and mIRL are influenced by image degradation caused by optical density filters as a model for media opacities. An underestimation of the thickness of these layers was observed, caused by a shift of retinal layer boundary placement due to image quality loss. This underestimation is not the same for each individual and also differed between the pRNFL and mIRL thickness measurements. These individual and interindividual differences demonstrate that an individual approach will be necessary to correct for this underestimation per layer.
Details
- Title: Subtitle
- Optical density filters modeling media opacities cause decreased SD-OCT retinal layer thickness measurements with inter- and intra-individual variation
- Creators
- Stanley Darma - Department of Ophthalmology, Academic Medical Center, Amsterdam, The NetherlandsPauline H B Kok - Department of Ophthalmology, Academic Medical Center, Amsterdam, The NetherlandsThomas J T P van den Berg - Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, Amsterdam, The NetherlandsMichael D Abràmoff - Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, Iowa, USADirk J Faber - Biomedical Engineering and Physics, Academic Medical Center, Amsterdam, The NetherlandsCaroline A Hulsman - Department of Ophthalmology, Academic Medical Center, Amsterdam, The NetherlandsFrank Zantvoord - Department of Ophthalmology, Academic Medical Center, Amsterdam, The NetherlandsMaarten P Mourits - Department of Ophthalmology, Academic Medical Center, Amsterdam, The NetherlandsReinier O Schlingemann - Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, Amsterdam, The NetherlandsFrank D Verbraak - Biomedical Engineering and Physics, Academic Medical Center, Amsterdam, The Netherlands
- Resource Type
- Journal article
- Publication Details
- Acta ophthalmologica, Vol.93(4), pp.355-361
- DOI
- 10.1111/aos.12596
- PMID
- 25487761
- NLM abbreviation
- Acta Ophthalmol
- ISSN
- 1755-375X
- eISSN
- 1755-3768
- Publisher
- England
- Language
- English
- Date published
- 06/2015
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Electrical and Computer Engineering; Ophthalmology and Visual Sciences
- Record Identifier
- 9983805901402771
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