Journal article
Optimal Management for Primary High Grade Ta Bladder Cancer: Role of re-staging TURBT and Intravesical Adjuvant Therapy
BJUI compass, Vol.5(8), pp.799-805
08/2024
DOI: 10.1002/bco2.363
PMCID: PMC11327485
PMID: 39157168
Abstract
ObjectiveThis study aims to investigate the impact of risk group classification, restaging transurethral resection (re-TURBT), and adjuvant treatment intensity on recurrence and progression risks in high-grade Ta tumours in patients with non-muscle invasive bladder cancer (NMIBC).Materials and methodsData from a comprehensive bladder cancer database were utilized for this study. Patients with primary high-grade Ta tumours were included. Risk groups were classified according to AUA/SUO criteria. Tumour characteristics and patient demographics were analysed using descriptive statistics. Cox proportional hazard regression models were used to assess the effect of re-TURBT and other clinical/treatment-related predictors on recurrence- and progression-free survivals. The survivals by selected predictors were estimated using Kaplan-Meier method, and groups were compared by the log-rank test.ResultsAmong 218 patients with high-grade Ta bladder cancer, those who underwent re-TURBT had significantly better 5-year recurrence-free survival (71.1% vs. 26.8%, p = 0.0009) and progression-free survival (98.6% vs. 73%, p = 0.0018) compared with those with initial TURBT alone. Full BCG treatment (induction and maintenance) showed lower recurrence risk, especially in high-risk patients. However, residual disease at re-TURBT did not significantly affect recurrence risk.ConclusionsThis study highlights the significance of risk group classification, the role of re-TURBT, and the intensity of adjuvant treatment in the management of high-grade Ta tumours. A risk-adapted model is crucial to reduce the burden of unnecessary intravesical treatment and endoscopic procedures.
Details
- Title: Subtitle
- Optimal Management for Primary High Grade Ta Bladder Cancer: Role of re-staging TURBT and Intravesical Adjuvant Therapy
- Creators
- Tarek Ajami - University of MiamiSunwoo Han - University of MiamiRuben Blachman-Braun - University of MiamiHelen Y. Hougen - University of IowaYuval Avda - University of MiamiMark L. Gonzalgo - University of MiamiBruno Nahar - University of MiamiSanoj Punnen - University of MiamiDipen J. Parekh - University of MiamiIsildinha M. Reis - University of MiamiChad R. Ritch - University of Miami
- Resource Type
- Journal article
- Publication Details
- BJUI compass, Vol.5(8), pp.799-805
- Publisher
- Wiley
- DOI
- 10.1002/bco2.363
- PMID
- 39157168
- PMCID
- PMC11327485
- ISSN
- 2688-4526
- eISSN
- 2688-4526
- Number of pages
- 7
- Language
- English
- Date published
- 08/2024
- Academic Unit
- Urology
- Record Identifier
- 9984701642302771
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