Optimal number of beams for stereotactic body radiotherapy of lung and liver lesions

Ruiguo Liu; John M Buatti; Terese L Howes; John Dill; Joseph M Modrick; Sanford L Meeks

doi:10.1016/j.ijrobp.2006.05.014

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Optimal number of beams for stereotactic body radiotherapy of lung and liver lesions

Journal article

Peer reviewed

Optimal number of beams for stereotactic body radiotherapy of lung and liver lesions

Ruiguo Liu, John M Buatti, Terese L Howes, John Dill, Joseph M Modrick and Sanford L Meeks

International journal of radiation oncology, biology, physics, Vol.66(3), pp.906-912

2006

DOI: 10.1016/j.ijrobp.2006.05.014

PMID: 16904842

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Abstract

Purpose: The aim of this study was to determine the optimal number of coplanar and noncoplanar external beams in the setting of stereotactic body radiotherapy (SBRT). Methods and Materials: Spherical targets were delineated within 2 separate extracranial sites, the lung and liver, with diameters varying from 2 cm to 7 cm to cover the range of volumes used in SBRT. Treatment plans were created for all target volumes using 5 to 15 geometrically optimized coplanar and noncoplanar conformal beams. Dose gradient and normal tissue complication probability (NTCP) were evaluated for each set of beam configurations and for each target size. Results: For all lung and liver target volumes, the dose gradient improved with an increase in beam number from 5 to 15 for both coplanar and noncoplanar beam configurations. NTCP decreased as the beam number increased from 5 to 9 beams for all target sizes for both coplanar and noncoplanar beams. There is no significant improvement in NTCP when more than 9 beams were used for treatment planning regardless of target size. Conclusion: Based on dosimetric criteria, the optimal number of external beams is 13 to 15 for SBRT using either coplanar or noncoplanar beam bouquets. Simple biologic models indicate that the optimal number of beams is 9 for SBRT of lung and liver lesions >2 cm, whereas smaller lesions may benefit from plans using up to 13 beams.

Stereotactic body radiotherapy

Geometric optimization

Lesions

Lung

Liver

Details

Title: Subtitle: Optimal number of beams for stereotactic body radiotherapy of lung and liver lesions
Creators: Ruiguo Liu - Robert Boissoneault Oncology Institute, Ocala, FL
John M Buatti - Department of Radiation Oncology, University of Iowa, Iowa City, IA
Terese L Howes - Department of Radiation Oncology, University of Iowa, Iowa City, IA
John Dill - Department of Radiation Oncology, University of Iowa, Iowa City, IA
Joseph M Modrick - Department of Radiation Oncology, University of Iowa, Iowa City, IA
Sanford L Meeks - M. D. Anderson Cancer Center Orlando, Orlando, FL
Resource Type: Journal article
Publication Details: International journal of radiation oncology, biology, physics, Vol.66(3), pp.906-912
DOI: 10.1016/j.ijrobp.2006.05.014
PMID: 16904842
NLM abbreviation: Int J Radiat Oncol Biol Phys
ISSN: 0360-3016
eISSN: 1879-355X
Publisher: Elsevier Inc
Language: English
Date published: 2006
Academic Unit: Radiation Oncology; Neurosurgery; Otolaryngology
Record Identifier: 9984040472202771

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