Journal article
Optimising drug therapy for non-infectious uveitis
International ophthalmology, Vol.39(7), pp.1633-1650
07/01/2019
DOI: 10.1007/s10792-018-0984-1
PMID: 29961190
Abstract
Uveitis encompasses a wide variety of sight-threatening diseases characterized by intraocular inflammation. It is often classified as infectious and non-infectious uveitis. Unlike infectious uveitis, a distinct infectious agent cannot be identified in non-infectious uveitis and disease origin is usually autoimmune, drug related, or idiopathic.
Non-infectious uveitis can often have a relapsing-remitting course, making it difficult to treat, and poses a significant challenge to ophthalmologists. The autoimmune nature of non-infectious uveitis warrants the use of anti-inflammatory and immunomodulatory agents for disease control. However, a subset of patients has persistent or recurrent ocular inflammation despite appropriate treatment, stressing the need for newer therapies aimed at more specific inflammatory targets such as tumour necrosis factor (TNF) alpha agents, anti-interleukin agents, and anti-interleukin receptor agents.
This article discusses the various medical options available for the treatment of non-infectious uveitis in the light of the most recent evidence.
Successful management of non-infectious uveitis requires the clinician carefully balance advantages and disadvantages of each new and old therapy while considering individual circumstances. Counselling regarding the benefits and complications of each therapy can help patients make an informed choice.
Details
- Title: Subtitle
- Optimising drug therapy for non-infectious uveitis
- Creators
- Mohammad Ali Shahab - Aga Khan UniversityTahreem Aman Mir - Johns Hopkins MedicineSidra Zafar - Aga Khan University
- Resource Type
- Journal article
- Publication Details
- International ophthalmology, Vol.39(7), pp.1633-1650
- DOI
- 10.1007/s10792-018-0984-1
- PMID
- 29961190
- ISSN
- 0165-5701
- eISSN
- 1573-2630
- Language
- English
- Date published
- 07/01/2019
- Academic Unit
- Ophthalmology and Visual Sciences
- Record Identifier
- 9984755395802771
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