Journal article
Optimized 3D Ultrashort Echo Time Pulmonary MRI
Magnetic resonance in medicine, Vol.70(5), pp.1241-1250
11/01/2013
DOI: 10.1002/mrm.24570
PMCID: PMC4199575
PMID: 23213020
Abstract
PurposeTo optimize 3D radial ultrashort echo time MRI for high resolution whole-lung imaging.
Methods3D radial ultrashort echo time was implemented on a 3T scanner to investigate the effects of: (1) limited field-of-view excitation, (2) variable density readouts, and (3) radial oversampling. Improvements in noise performance and spatial resolution were assessed through simulation and phantom studies. Their effects on lung and airway visualization in five healthy male human subjects (mean age 32 years) were compared qualitatively through blinded ordinal scoring by two cardiothoracic radiologists using a nonparametric Friedman test (P < 0.05). Relative signal difference between endobronchial air and adjacent lung tissue, normalized to nearby vessel, was used as a surrogate for lung tissue signal. Quantitative measures were compared using the paired Student's t-test (P < 0.05). Finally, clinical feasibility was investigated in a patient with interstitial fibrosis.
ResultsSimulation and phantom studies showed up to 67% improvement in SNR and reduced blurring for short T2* species using all three optimizations. In vivo images showed decreased artifacts and improved lung tissue and airway visualization both qualitatively and quantitatively.
ConclusionThe use of limited field-of-view excitation, variable readout gradients, and radial oversampling significantly improve the technical quality of 3D radial ultrashort echo time lung images. Magn Reson Med 70:1241-1250, 2013. (c) 2012 Wiley Periodicals, Inc.
Details
- Title: Subtitle
- Optimized 3D Ultrashort Echo Time Pulmonary MRI
- Creators
- Kevin M. Johnson - University of Wisconsin–MadisonSean B. Fain - University of Wisconsin–MadisonMark L. Schiebler - University of Wisconsin–MadisonScott Nagle - University of Wisconsin–Madison
- Resource Type
- Journal article
- Publication Details
- Magnetic resonance in medicine, Vol.70(5), pp.1241-1250
- Publisher
- Wiley
- DOI
- 10.1002/mrm.24570
- PMID
- 23213020
- PMCID
- PMC4199575
- ISSN
- 0740-3194
- eISSN
- 1522-2594
- Number of pages
- 10
- Grant note
- UW School of Medicine and Public Health R01NS066982; R01HL072260-05 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA UL1TR000427 / NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS) R01NS066982 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) UL1RR025011 / NATIONAL CENTER FOR RESEARCH RESOURCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) R01HL072260 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) 1UL1RR025011 / National Center for Research Resources; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) 9U54TR000021 / National Center for Advancing Translational Sciences; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS)
- Language
- English
- Date published
- 11/01/2013
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Electrical and Computer Engineering; Health and Human Physiology
- Record Identifier
- 9984274956602771
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