Journal article
Optimizing Advances in Nanoparticle Delivery for Cancer Immunotherapy
Advanced drug delivery reviews, Vol.144, pp.3-15
04/2019
DOI: 10.1016/j.addr.2019.07.009
PMID: 31330165
Abstract
Cancer immunotherapy is one of the fastest growing and most promising fields in clinical oncology. T-cell checkpoint inhibitors are revolutionizing the management of advanced cancers including non-small cell lung cancer and melanoma. Unfortunately, many common cancers are not responsive to these drugs and resistance remains problematic. A growing number of novel cancer immunotherapies have been discovered but their clinical translation has been limited by shortcomings of conventional drug delivery. Immune signaling is tightly-regulated and often requires simultaneous or near-simultaneous activation of multiple signals in specific subpopulations of immune cells. Nucleic acid therapies, which require intact intracellular delivery, are among the most promising approaches to modulate the tumor microenvironment to a pro-immunogenic phenotype. Advanced nanomedicines can be precisely engineered to overcome many of these limitations and appear well-poised to enable the clinical translation of promising cancer immunotherapies.
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Details
- Title: Subtitle
- Optimizing Advances in Nanoparticle Delivery for Cancer Immunotherapy
- Creators
- Joseph M. Caster - University of IowaCameron Callaghan - University of IowaSteven N. Seyedin - University of IowaKelly Henderson - University of IowaBo Sun - University of North Carolina at Chapel HillAndrew Z. Wang - University of North Carolina at Chapel Hill
- Resource Type
- Journal article
- Publication Details
- Advanced drug delivery reviews, Vol.144, pp.3-15
- Publisher
- Elsevier B.V
- DOI
- 10.1016/j.addr.2019.07.009
- PMID
- 31330165
- ISSN
- 0169-409X
- eISSN
- 1872-8294
- Grant note
- name: National Institutes of Health/National Cancer Institute, award: U54CA198999, R01 EB25651; DOI: 10.13039/100000005, name: Department of Defense, award: W81XWH-16-1-0530; name: The University of North Carolina’s Research Opportunities Initiative grant
- Language
- English
- Date published
- 04/2019
- Academic Unit
- Radiation Oncology
- Record Identifier
- 9984312972702771
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