Optimizing the Program-Specific Reporting of Pancreas Transplant Outcomes

B. L. Kasiske; S. Gustafson; N. Salkowski; P. G. Stock; D. A. Axelrod; R. Kandaswamy; E. F. Sleeman; J. Wainright; A. K. Israni; J. J. Snyder

doi:10.1111/ajt.12036

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Optimizing the Program-Specific Reporting of Pancreas Transplant Outcomes

Journal article

Open access

Peer reviewed

Optimizing the Program-Specific Reporting of Pancreas Transplant Outcomes

B. L. Kasiske, S. Gustafson, N. Salkowski, P. G. Stock, D. A. Axelrod, R. Kandaswamy, E. F. Sleeman, J. Wainright, A. K. Israni and J. J. Snyder

American journal of transplantation, Vol.13(2), pp.337-347

02/01/2013

DOI: 10.1111/ajt.12036

PMID: 23289524

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Abstract

The Scientific Registry of Transplant Recipients is charged with providing program-specific reports for organ transplant programs in the United States. Monitoring graft survival for pancreas transplant programs has been problematic as there are three different pancreas transplant procedures that may have different outcomes, and analyzing them separately reduces events and statistical power. We combined two consecutive 2.5-year cohorts of transplant recipients to develop Cox proportional hazards models predicting outcomes, and tested these models in the second 2.5-year cohort. We used separate models for 1- and 3-year graft and patient survival for each transplant type: simultaneous pancreaskidney (SPK), pancreas after kidney (PAK) and pancreas transplant alone (PTA). We first built a predictive model for each pancreas transplant type, and then pooled the transplant types within centers to compare total observed events with total predicted events. Models for 1-year pancreas graft and patient survival yielded C statistics of 0.65 (95% confidence interval, 0.630.68) and 0.66 (0.610.72), respectively, comparable to C statistics for 1-year patient and graft survival for other organ transplants. Model calibration (HosmerLemeshow method) was also acceptable. We conclude that pooling the results of SPK, PAK and PTA can produce potentially useful models for reporting program-specific pancreas transplant outcomes.

Life Sciences & Biomedicine

Science & Technology

Surgery

Transplantation

Details

Title: Subtitle: Optimizing the Program-Specific Reporting of Pancreas Transplant Outcomes
Creators: B. L. Kasiske - Hennepin County Medical Center
S. Gustafson - Medical Research Foundation
N. Salkowski - Medical Research Foundation
P. G. Stock - University of California, San Francisco
D. A. Axelrod - Dartmouth–Hitchcock Medical Center
R. Kandaswamy - University of Minnesota
E. F. Sleeman - United Network for Organ Sharing Richmond VA
J. Wainright - United Network for Organ Sharing Richmond VA
A. K. Israni - Hennepin County Medical Center
J. J. Snyder - University of Minnesota
Resource Type: Journal article
Publication Details: American journal of transplantation, Vol.13(2), pp.337-347
DOI: 10.1111/ajt.12036
PMID: 23289524
NLM abbreviation: Am J Transplant
ISSN: 1600-6135
eISSN: 1600-6143
Publisher: Wiley
Number of pages: 11
Grant note: US Government HHSH250201000018C / Minneapolis Medical Research Foundation
Language: English
Date published: 02/01/2013
Academic Unit: Surgery
Record Identifier: 9984322947902771

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