Journal article
Optogenetic inhibition of cocaine seeking in rats
Addiction biology, Vol.18(1), pp.50-53
01/2013
DOI: 10.1111/j.1369-1600.2012.00479.x
PMCID: PMC3578202
PMID: 22823160
Abstract
Inhibitory optogenetics was used to examine the roles of the prelimbic cortex (PL), the nucleus accumbens core (NAcore) and the PL projections to the NAcore in the reinstatement of cocaine seeking. Rats were microinjected into the PL or NAcore with an adeno‐associated virus containing halorhodopsin or archaerhodopsin. After 12 days of cocaine self‐administration, followed by extinction training, animals underwent reinstatement testing along with the presence/absence of optically induced inhibition via laser light. Bilateral optical inhibition of the PL, NAcore or the PL fibers in the NAcore inhibited the reinstatement of cocaine seeking.
Details
- Title: Subtitle
- Optogenetic inhibition of cocaine seeking in rats
- Creators
- Michael T Stefanik - Medical University of South CarolinaKhaled Moussawi - Medical University of South CarolinaYonatan M Kupchik - Medical University of South CarolinaKyle C Smith - Medical University of South CarolinaRachel L Miller - University of IowaMary L Huff - University of IowaKarl Deisseroth - Stanford UniversityPeter W Kalivas - Medical University of South CarolinaRyan T LaLumiere - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Addiction biology, Vol.18(1), pp.50-53
- DOI
- 10.1111/j.1369-1600.2012.00479.x
- PMID
- 22823160
- PMCID
- PMC3578202
- NLM abbreviation
- Addict Biol
- ISSN
- 1355-6215
- eISSN
- 1369-1600
- Number of pages
- 4
- Grant note
- National Institutes of Health (DA027055; DA015369; DA003906; T32 DA7288)
- Language
- English
- Date published
- 01/2013
- Academic Unit
- Psychological and Brain Sciences; Iowa Neuroscience Institute
- Record Identifier
- 9984070997902771
Metrics
33 Record Views