Journal article
Oral Bioavailability of Slow-Release Theophylline from Unencapsulated Beads in Preschool Children with Chronic Asthma
Therapeutic drug monitoring, Vol.10(4), pp.395-400
12/1988
DOI: 10.1097/00007691-198804000-00005
PMID: 3059587
Abstract
The relative bioavailability of two slow-release theophylline formulations using bead-filled capsules, Slo-bid and Theo-Dur Sprinkle, was examined in randomized crossover multiple-dose trials using collected saliva. Two groups of seven preschool-age asthmatic children received one of these and Slo-Phyllin Gyrocaps as a reference. Dose-normalized areas under the saliva concentration-time curves were significantly less than the reference for Theo-Dur Sprinkle (p = .02) but not for Slo-bid with the relative bioavailability determinations of 66 ± 8% (mean ± SEM) and 109 ± 5% for Theo-Dur Sprinkle and Slo-bid, respectively. The less complete absorption of Theo-Dur Sprinkle during clinical use in preschool-age children is consistent with the malabsorptive effects of food previously reported for the former but not the latter formulation. © 1988 Raven Press, Ltd., New York.
Details
- Title: Subtitle
- Oral Bioavailability of Slow-Release Theophylline from Unencapsulated Beads in Preschool Children with Chronic Asthma
- Creators
- Leigh M. Vaughan - University of IowaGary MilavetzMiles M. WeinbergerGary D. SmithJames B. Harris
- Resource Type
- Journal article
- Publication Details
- Therapeutic drug monitoring, Vol.10(4), pp.395-400
- DOI
- 10.1097/00007691-198804000-00005
- PMID
- 3059587
- ISSN
- 0163-4356
- eISSN
- 1536-3694
- Language
- English
- Date published
- 12/1988
- Academic Unit
- Pharmacy; Stead Family Department of Pediatrics; Pharmacy Practice and Science
- Record Identifier
- 9984365901802771
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