Journal article
Oral antibiotic treatment and long-term outcomes of Lyme facial nerve palsy
Infection, Vol.39(3), pp.239-245
06/2011
DOI: 10.1007/s15010-011-0107-7
PMID: 21523405
Abstract
To study the long-term functional outcomes of patients with Lyme facial nerve palsy treated with oral antibiotics.We conducted a retrospective double-cohort study involving patients with Lyme facial nerve palsy treated with oral antibiotics matched to three controls with early localized Lyme disease. Chart review was completed and an SF-36 health questionnaire and standardized symptom questionnaire administered.Lyme facial nerve palsy patients were treated with oral antibiotics for a median duration of 21 days (range 7–30 days). Only three patients underwent lumbar puncture and each demonstrated lymphocytic pleocytosis. Fourteen of 15 patients with Lyme facial nerve palsy completely regained nerve function. The long-term outcomes were similar between patients with Lyme facial nerve palsy and controls after a median follow-up duration of 4.6 years. Patients with Lyme facial nerve palsy had significantly higher reported rates of fatigue (60%) than controls (27%) (p = 0.019), but similar energy and vitality scores on the SF-36 questionnaire (55.0 vs. 58.4, p = 0.621). SF-36 social functioning domain scores were significantly lower in patients with Lyme facial nerve palsy (77.5) than in controls (88.6) (p = 0.044). There were no other significant differences noted between the two cohorts.For patients with Lyme facial nerve palsy in North America, treatment with oral doxycycline appears to be an effective therapeutic strategy.
Details
- Title: Subtitle
- Oral antibiotic treatment and long-term outcomes of Lyme facial nerve palsy
- Creators
- T Kowalski - Section of Infectious Disease Gundersen Lutheran Health System 1900 South Avenue, C04-001 La Crosse WI 54601 USAW Berth - Medical Research Gundersen Lutheran Medical Foundation La Crosse WI USAM Mathiason - Medical Research Gundersen Lutheran Medical Foundation La Crosse WI USAW Agger - Section of Infectious Disease Gundersen Lutheran Health System 1900 South Avenue, C04-001 La Crosse WI 54601 USA
- Resource Type
- Journal article
- Publication Details
- Infection, Vol.39(3), pp.239-245
- Publisher
- Springer-Verlag
- DOI
- 10.1007/s15010-011-0107-7
- PMID
- 21523405
- ISSN
- 0300-8126
- eISSN
- 1439-0973
- Language
- English
- Date published
- 06/2011
- Academic Unit
- General Internal Medicine; Internal Medicine
- Record Identifier
- 9984094664902771
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