Oral clefts, transforming growth factor alpha gene variants, and maternal smoking : A population-based case-control study in Denmark, 1991-1994

Kaare Christensen; Jøm  Olsen; B NORGAARD-PEDERSEN; O BASSO; H STØVRING; L MILHOLLIN-JOHNSON; J. C MURRAY

doi:10.1093/oxfordjournals.aje.a009799

Back

Oral clefts, transforming growth factor alpha gene variants, and maternal smoking : A population-based case-control study in Denmark, 1991-1994

Journal article

Open access

Peer reviewed

Oral clefts, transforming growth factor alpha gene variants, and maternal smoking : A population-based case-control study in Denmark, 1991-1994

Kaare Christensen, Jøm Olsen, B NORGAARD-PEDERSEN, O BASSO, H STØVRING, L MILHOLLIN-JOHNSON and J. C MURRAY

American journal of epidemiology, Vol.149(3), pp.248-255

1999

DOI: 10.1093/oxfordjournals.aje.a009799

PMID: 9927220

Files and links (1)

url

https://doi.org/10.1093/oxfordjournals.aje.a009799View

Published (Version of record) Open Access

Abstract

Studies in the United States have indicated that maternal first trimester smoking and infant transforming growth factor alpha (TGFA) locus mutations are associated with non-syndromic cleft lip and/or palate (CLP) and that a synergistic effect of these two risk factors occurs. Based on a Danish case-control study of CLP, the authors studied the effects of smoking and TGFA alleles in an ethnically homogeneous setting. Interview information was obtained for mothers of 302 CLP cases (96% of eligible) and for 567 mothers of nonmalformed children (94% of eligible). Multivariate logistic regression analyses revealed that smoking was associated with a moderately increased risk of cleft lip +/- cleft palate (CL(P)) (odds ratio = 1.40, 95% confidence interval 0.99-2.00). No association between smoking and isolated cleft palate (CP) was observed. TGFA genotype was not associated with either CL(P) or CP, and no synergistic effect with smoking was observed. The "rare" TGFA allele occurred in 25% of both cases and controls compared with an average of 14% in other white control groups. Furthermore, the frequency of CLP in Scandinavia is among the highest in the world. Hence, it is possible that the previously reported association between TGFA and CLP to some degree can be attributable to confounding by ethnicity.

Epidemiology

Public health. Hygiene-occupational medicine

Public health. Hygiene

General aspects

Analysis. Health state

Biological and medical sciences

Medical sciences

Details

Title: Subtitle: Oral clefts, transforming growth factor alpha gene variants, and maternal smoking : A population-based case-control study in Denmark, 1991-1994
Creators: Kaare Christensen - Institute of Public Health, Epidemiology, Odense University, Winslowparken, Odense, Denmark
Jøm Olsen - The Danish Epidemiology Science Centre, Aarhus University, Aarhus, Denmark
B NORGAARD-PEDERSEN - The State Serum Institute, Copenhagen, Denmark
O BASSO - The Danish Epidemiology Science Centre, Aarhus University, Aarhus, Denmark
H STØVRING - Institute of Public Health, Epidemiology, Odense University, Winslowparken, Odense, Denmark
L MILHOLLIN-JOHNSON - Department of Pediatrics, University of Iowa, Iowa City, IA, United States
J. C MURRAY - Department of Pediatrics, University of Iowa, Iowa City, IA, United States
Resource Type: Journal article
Publication Details: American journal of epidemiology, Vol.149(3), pp.248-255
DOI: 10.1093/oxfordjournals.aje.a009799
PMID: 9927220
NLM abbreviation: Am J Epidemiol
ISSN: 0002-9262
eISSN: 1476-6256
Publisher: Oxford University Press; Cary, NC
Language: English
Date published: 1999
Academic Unit: Anatomy and Cell Biology; Stead Family Department of Pediatrics; Epidemiology; Pediatric Dentistry; Craniofacial Anomalies Research Center; Dental Research
Record Identifier: 9984025557802771

Metrics

12 Record Views

79 Times Cited - Web of Science