Oral vs intratympanic corticosteroid therapy for idiopathic sudden sensorineural hearing loss: a randomized trial

Steven D Rauch; Christopher F Halpin; Patrick J Antonelli; Seilesh Babu; John P Carey; Bruce J Gantz; Joel A Goebel; Paul E Hammerschlag; Jeffrey P Harris; Brandon Isaacson; Daniel Lee; Christopher J Linstrom; Lorne S Parnes; Helen Shi; William H Slattery; Steven A Telian; Jeffrey T Vrabec; Domenic J Reda

doi:10.1001/jama.2011.679

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Oral vs intratympanic corticosteroid therapy for idiopathic sudden sensorineural hearing loss: a randomized trial

Journal article

Open access

Peer reviewed

Oral vs intratympanic corticosteroid therapy for idiopathic sudden sensorineural hearing loss: a randomized trial

Steven D Rauch, Christopher F Halpin, Patrick J Antonelli, Seilesh Babu, John P Carey, Bruce J Gantz, Joel A Goebel, Paul E Hammerschlag, Jeffrey P Harris, Brandon Isaacson, …

JAMA : the journal of the American Medical Association, Vol.305(20), pp.2071-2079

05/25/2011

DOI: 10.1001/jama.2011.679

PMID: 21610239

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Abstract

Idiopathic sudden sensorineural hearing loss has been treated with oral corticosteroids for more than 30 years. Recently, many patients' symptoms have been managed with intratympanic steroid therapy. No satisfactory comparative effectiveness study to support this practice exists.

Acute Disease

Glucocorticoids - administration & dosage

Prednisone - administration & dosage

Prednisone - adverse effects

Prospective Studies

Administration, Oral

Humans

Middle Aged

Male

Methylprednisolone - adverse effects

Treatment Outcome

Young Adult

Adolescent

Aged, 80 and over

Tympanic Membrane - drug effects

Adult

Female

Aged

Hearing Loss, Sensorineural - drug therapy

Glucocorticoids - adverse effects

Methylprednisolone - administration & dosage

Details

Title: Subtitle: Oral vs intratympanic corticosteroid therapy for idiopathic sudden sensorineural hearing loss: a randomized trial
Creators: Steven D Rauch - Department of Otology and Laryngology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, 243 Charles St, Boston, MA 02114, USA. steven_rauch@meei.harvard.edu
Christopher F Halpin
Patrick J Antonelli
Seilesh Babu
John P Carey
Bruce J Gantz
Joel A Goebel
Paul E Hammerschlag
Jeffrey P Harris
Brandon Isaacson
Daniel Lee
Christopher J Linstrom
Lorne S Parnes
Helen Shi
William H Slattery
Steven A Telian
Jeffrey T Vrabec
Domenic J Reda
Resource Type: Journal article
Publication Details: JAMA : the journal of the American Medical Association, Vol.305(20), pp.2071-2079
DOI: 10.1001/jama.2011.679
PMID: 21610239
NLM abbreviation: JAMA
ISSN: 0098-7484
eISSN: 1538-3598
Publisher: United States
Grant note: U01-DC006296 / NIDCD NIH HHS
Language: English
Date published: 05/25/2011
Academic Unit: Neurosurgery; Otolaryngology
Record Identifier: 9984006300602771

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