Journal article
Orbital Necrobiotic Xanthogranuloma Associated With Systemic IgG4 Disease
Ocular immunology and inflammation, Vol.18(5), pp.373-378
10/2010
DOI: 10.3109/09273948.2010.490629
PMID: 20716008
Abstract
Purpose: The authors describe 2 cases of orbital xanthogranulomatous disease associated with an increase in IgG4-positive plasma cells, and also examine IgG4 in other types of orbital inflammation.
Methods: Immunohistochemistry for total IgG and IgG4 was performed in 18 cases of orbital inflammation, including chronic dacryoadenitis (n = 10), necrobiotic xanthogranuloma (n = 2), xanthogranuloma (n = 1), idiopathic orbital inflammation/pseudotumor (n = 4), and fungal infection (n = 1).
Results: One patient presenting with necrobiotic xanthogranuloma had signs of systemic IgG4 disease. His orbital lesion showed an elevated number of IgG4 positive plasma cells (55%). An orbital xanthogranulomatous lesion in a second patient lacking systemic symptoms also contained a high percentage of IgG4-positive plasma cells (80%). Only 1 case of chronic dacryoadenitis contained prominent IgG4-positive plasma cells (mean 17/hpf).
Conclusions: IgG4-positive plasma cells are relatively rare in nonsclerosing orbital inflammatory lesions. However, systemic disease IgG4 can be associated with necrobiotic xanthogranuloma of the orbit.
Details
- Title: Subtitle
- Orbital Necrobiotic Xanthogranuloma Associated With Systemic IgG4 Disease
- Creators
- Kamaljeet Singh - 1Brown University, Pathology, Providence, RI, United StatesK D A Rajan - 2Wilmer Eye Institute, Johns Hopkins Medical Institutions, Baltimore, MD, United StatesCharles Eberhart - 3The Johns Hopkins School of Medicine, Pathology, Baltimore, MD, United States
- Resource Type
- Journal article
- Publication Details
- Ocular immunology and inflammation, Vol.18(5), pp.373-378
- Publisher
- Informa Healthcare
- DOI
- 10.3109/09273948.2010.490629
- PMID
- 20716008
- ISSN
- 0927-3948
- eISSN
- 1744-5078
- Language
- English
- Date published
- 10/2010
- Academic Unit
- Pathology
- Record Identifier
- 9984047789202771
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