Journal article
Orexin receptors 1 and 2 in serotonergic neurons differentially regulate peripheral glucose metabolism in obesity
Nature communications, Vol.12(1), pp.1-20
09/01/2021
DOI: 10.1038/s41467-021-25380-2
PMCID: PMC8413382
PMID: 34475397
Abstract
The wake-active orexin system plays a central role in the dynamic regulation of glucose homeostasis. Here the authors report that inactivation of the orexin receptor type 1 or 2 in serotonergic neurons differentially regulate systemic glucose homeostasis in the context of diet induced obesity.
Details
- Title: Subtitle
- Orexin receptors 1 and 2 in serotonergic neurons differentially regulate peripheral glucose metabolism in obesity
- Creators
- Xing Xiao - Max Planck Institute for Metabolism Research, Department of Neuronal Control of MetabolismGagik Yeghiazaryan - Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD) and Center for Molecular Medicine Cologne (CMMC), University of CologneSimon Hess - Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD) and Center for Molecular Medicine Cologne (CMMC), University of ColognePaul Klemm - Max Planck Institute for Metabolism Research, Department of Neuronal Control of MetabolismAnna Sieben - Max Planck Institute for Metabolism Research, Department of Neuronal Control of MetabolismAndré Kleinridders - Max Planck Institute for Metabolism Research, Department of Neuronal Control of MetabolismDonald A. Morgan - Department of Neuroscience and Pharmacology, University of Iowa, Carver College of MedicineF. Thomas Wunderlich - Max Planck Institute for Metabolism Research, Department of Neuronal Control of MetabolismKamal Rahmouni - Department of Neuroscience and Pharmacology, University of Iowa, Carver College of MedicineDong Kong - Division of Endocrinology, Department of Pediatrics, F.M. Kirby Neurobiology Center, Boston Children’s Hospital and Harvard Medical SchoolThomas E. Scammell - Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical SchoolBradford B. Lowell - Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical SchoolPeter Kloppenburg - Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD) and Center for Molecular Medicine Cologne (CMMC), University of CologneJens C. Brüning - Max Planck Institute for Metabolism Research, Department of Neuronal Control of MetabolismA. Christine Hausen - Max Planck Institute for Metabolism Research, Department of Neuronal Control of Metabolism
- Resource Type
- Journal article
- Publication Details
- Nature communications, Vol.12(1), pp.1-20
- Publisher
- Nature Publishing Group
- DOI
- 10.1038/s41467-021-25380-2
- PMID
- 34475397
- PMCID
- PMC8413382
- eISSN
- 2041-1723
- Language
- English
- Date published
- 09/01/2021
- Academic Unit
- Iowa Neuroscience Institute; Fraternal Order of Eagles Diabetes Research Center; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984128504702771
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