Journal article
Organ-Level Histological and Biomechanical Responses from Localized Osteoarticular Injury in the Rabbit Knee
Journal of orthopaedic research, Vol.29(3), pp.340-346
03/2011
DOI: 10.1002/jor.21259
PMCID: PMC3700429
PMID: 20886656
Abstract
The processes of whole-joint osteoarthritis development following localized joint injuries are not well understood. To demonstrate this local-to-global linkage, it was hypothesized that a localized osteoarticular injury in the rabbit knee would not only cause biomechanical and histological abnormalities in the involved compartment, but also concurrent histological changes in the non-involved compartment. Twenty rabbits had an acute osteoarticular injury that involved localized joint incongruity (a 2 mm osteochondral defect created in the weight-bearing area of the medial femoral condyle), while another twenty received control sham surgery. At the time of sacrifice at eight or sixteen weeks post-surgery, the experimental knees were subjected to sagittal-plane laxity measurement, followed by cartilage histo-morphological evaluation using the Mankin score. The immediate effects of defect creation on joint stability and contact mechanics were explored in concomitant rabbit cadaver experimentation. The injured animals had cartilage histological scores significantly higher than in the sham surgery group (p<0.01) on the medial femoral, medial tibial, and lateral femoral surfaces (predominantly on the medial surfaces), accompanied by slight (mean 20%) increase of sagittal-plane laxity. Immediate injury-associated alterations in the medial compartment contact mechanics were also demonstrated. Localized osteoarticular injury in this survival animal model resulted in global joint histological changes.
Details
- Title: Subtitle
- Organ-Level Histological and Biomechanical Responses from Localized Osteoarticular Injury in the Rabbit Knee
- Creators
- Tanawat Vaseenon - Department of Orthopaedics and Rehabilitation, University of IowaYuki Tochigi - Department of Orthopaedics and Rehabilitation, University of IowaAnneliese D Heiner - Department of Orthopaedics and Rehabilitation, University of IowaJessica E Goetz - Department of Orthopaedics and Rehabilitation, University of IowaThomas E Baer - Department of Orthopaedics and Rehabilitation, University of IowaDouglas Fredericks - Department of Orthopaedics and Rehabilitation, University of IowaJames A Martin - Department of Orthopaedics and Rehabilitation, University of IowaM. James Rudert - Department of Orthopaedics and Rehabilitation, University of IowaStephen L Hillis - Center for Research in the Implementation of Innovative Strategies in Practice (CRIISP), VA Iowa City Medical Center, and Department of Biostatistics, the University of IowaThomas D Brown - Department of Orthopaedics and Rehabilitation, University of IowaTodd O McKinley - Department of Orthopaedics and Rehabilitation, University of Iowa
- Resource Type
- Journal article
- Publication Details
- Journal of orthopaedic research, Vol.29(3), pp.340-346
- DOI
- 10.1002/jor.21259
- PMID
- 20886656
- PMCID
- PMC3700429
- NLM abbreviation
- J Orthop Res
- ISSN
- 0736-0266
- eISSN
- 1554-527X
- Grant note
- P50 AR055533 || AR / National Institute of Arthritis and Musculoskeletal and Skin Diseases : NIAMS
- Language
- English
- Date published
- 03/2011
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Pharmaceutical Sciences and Experimental Therapeutics; Biostatistics; Orthopedics and Rehabilitation; Craniofacial Anomalies Research Center
- Record Identifier
- 9984040260102771
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