Organ of Corti potentials and the motion of the basilar membrane

Anders Fridberger; Jacques Boutet de Monvel; Jiefu Zheng; Ning Hu; Yuan Zou; Tianying Ren; Alfred Nuttall

doi:10.1523/JNEUROSCI.2711-04.2004

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Organ of Corti potentials and the motion of the basilar membrane

Journal article

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Peer reviewed

Organ of Corti potentials and the motion of the basilar membrane

Anders Fridberger, Jacques Boutet de Monvel, Jiefu Zheng, Ning Hu, Yuan Zou, Tianying Ren and Alfred Nuttall

The Journal of neuroscience, Vol.24(45), pp.10057-10063

11/10/2004

DOI: 10.1523/JNEUROSCI.2711-04.2004

PMCID: PMC6730184

PMID: 15537874

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Abstract

During sound stimulation, receptor potentials are generated within the sensory hair cells of the cochlea. Prevailing theory states that outer hair cells use the potential-sensitive motor protein prestin to convert receptor potentials into fast alterations of cellular length or stiffness that boost hearing sensitivity almost 1000-fold. However, receptor potentials are attenuated by the filter formed by the capacitance and resistance of the membrane of the cell. This attenuation would limit cellular motility at high stimulus frequencies, rendering the above scheme ineffective. Therefore, Dallos and Evans (1995a) proposed that extracellular potential changes within the organ of Corti could drive cellular motor proteins. These extracellular potentials are not filtered by the membrane. To test this theory, both electric potentials inside the organ of Corti and basilar membrane vibration were measured in response to acoustic stimulation. Vibrations were measured at sites very close to those interrogated by the recording electrode using laser interferometry. Close comparison of the measured electrical and mechanical tuning curves and time waveforms and their phase relationships revealed that those extracellular potentials indeed could drive outer hair cell motors. However, to achieve the sharp frequency tuning that characterizes the basilar membrane, additional mechanical processing must occur inside the organ of Corti.

cochlea

laser interferometry

guinea pig

outer hair cells

electromotility

basilar membrane

Details

Title: Subtitle: Organ of Corti potentials and the motion of the basilar membrane
Creators: Anders Fridberger - Karolinska Institutet
Jacques Boutet de Monvel - Karolinska Institutet
Jiefu Zheng - Karolinska Institutet
Ning Hu - Oregon Health & Science University
Yuan Zou - Oregon Health & Science University
Tianying Ren - Oregon Health & Science University
Alfred Nuttall - University of Michigan
Resource Type: Journal article
Publication Details: The Journal of neuroscience, Vol.24(45), pp.10057-10063
DOI: 10.1523/JNEUROSCI.2711-04.2004
PMID: 15537874
PMCID: PMC6730184
NLM abbreviation: J Neurosci
ISSN: 1529-2401
eISSN: 1529-2401
Language: English
Date published: 11/10/2004
Academic Unit: Biology
Record Identifier: 9984627337602771

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