Journal article
Organization of the mouse GP42/Basigin gene: a member of the Ig superfamily
Biochimica et biophysica acta. Gene structure and expression, Vol.1217(3), pp.307-311
1994
DOI: 10.1016/0167-4781(94)90290-9
PMID: 8148376
Abstract
We have mapped and sequenced the GP42/Basigin gene isolated from a Balb/C mouse genomic library. The genomic organization and upstream, putative regulatory, regions of this gene have not been previously reported. Our data show that exon 5 of the GP42/Basigin gene encodes the carboxy proximal half of the second Ig-like domain, the highly conserved transmembrane region and a portion of the cytoplasmic tail. This inclusion of Ig-like and other functional domains in a single exon is unusual. Splice junction analysis indicates that two reported alternate GP42/Basigin cDNA isoforms are likely due to cloning artifacts. In addition, we find that GP42/Basigin is polymorphic in mice. Our data also support the proposal that the transmembrane domain and portions of the cytoplasmic region of GP42/Basigin have been evolutionarily conserved.
Details
- Title: Subtitle
- Organization of the mouse GP42/Basigin gene: a member of the Ig superfamily
- Creators
- Yi ChengXiaobin LiJohn KamholzFrank R Burns
- Resource Type
- Journal article
- Publication Details
- Biochimica et biophysica acta. Gene structure and expression, Vol.1217(3), pp.307-311
- DOI
- 10.1016/0167-4781(94)90290-9
- PMID
- 8148376
- NLM abbreviation
- Biochim Biophys Acta
- ISSN
- 0167-4781
- eISSN
- 1879-2634
- Publisher
- Elsevier B.V
- Language
- English
- Date published
- 1994
- Academic Unit
- Neurology; Psychiatry
- Record Identifier
- 9984020850402771
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