Journal article
Organizing genome engineering for the gigabase scale
Nature communications, Vol.11(1), pp.689-689
02/04/2020
DOI: 10.1038/s41467-020-14314-z
PMCID: PMC7000699
PMID: 32019919
Abstract
Genome-scale engineering holds great potential to impact science, industry, medicine, and society, and recent improvements in DNA synthesis have enabled the manipulation of megabase genomes. However, coordinating and integrating the workflows and large teams necessary for gigabase genome engineering remains a considerable challenge. We examine this issue and recommend a path forward by: 1) adopting and extending existing representations for designs, assembly plans, samples, data, and workflows; 2) developing new technologies for data curation and quality control; 3) conducting fundamental research on genome-scale modeling and design; and 4) developing new legal and contractual infrastructure to facilitate collaboration.
Details
- Title: Subtitle
- Organizing genome engineering for the gigabase scale
- Creators
- Bryan A Bartley - RTXJacob Beal - RTXJonathan R Karr - Icahn School of Medicine at Mount SinaiElizabeth A Strychalski - National Institute of Standards and Technology
- Resource Type
- Journal article
- Publication Details
- Nature communications, Vol.11(1), pp.689-689
- DOI
- 10.1038/s41467-020-14314-z
- PMID
- 32019919
- PMCID
- PMC7000699
- ISSN
- 2041-1723
- eISSN
- 2041-1723
- Grant note
- P41 EB023912 / NIBIB NIH HHS R35 GM119771 / NIGMS NIH HHS
- Language
- English
- Date published
- 02/04/2020
- Academic Unit
- Electrical and Computer Engineering
- Record Identifier
- 9984627233302771
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