Journal article
Origins of Cystic Fibrosis Lung Disease
The New England journal of medicine, Vol.372(16), pp.1574-1575
04/16/2015
DOI: 10.1056/NEJMc1502191
PMID: 25875271
Abstract
To the Editor:
On the basis of their seminal findings in models of disease in large animals, Stoltz and colleagues (Jan. 22 issue)
1
report that the origins of cystic fibrosis lung disease result from impaired chloride and bicarbonate epithelial transport, defective mucociliary transport, and acidification of the airway-surface liquid. The pathophysiology of cystic fibrosis is deduced from the loss or dysfunction of CFTR in the apical epithelial membrane. However, this exclusive focus on the epithelial membrane ignores the roles of CFTR in intracellular compartments and in nonepithelial cells. An attenuated bacteria-killing capability has been reported in monocytes and macrophages isolated . . .
Details
- Title: Subtitle
- Origins of Cystic Fibrosis Lung Disease
- Creators
- Antje Munder - Hanover Medical School, Hannover, GermanyBurkhard Tümmler - Hanover Medical School, Hannover, GermanyDavid A Stoltz - University of Iowa Carver College of Medicine, Iowa City, IADavid K Meyerholz - University of Iowa Carver College of Medicine, Iowa City, IAMichael J Welsh - University of Iowa Carver College of Medicine, Iowa City, IA
- Resource Type
- Journal article
- Publication Details
- The New England journal of medicine, Vol.372(16), pp.1574-1575
- Publisher
- Massachusetts Medical Society
- DOI
- 10.1056/NEJMc1502191
- PMID
- 25875271
- ISSN
- 0028-4793
- eISSN
- 1533-4406
- Language
- English
- Date published
- 04/16/2015
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Neurology; Molecular Physiology and Biophysics; Pulmonary, Critical Care, and Occupational Medicine; Pathology; Neurosurgery; Internal Medicine
- Record Identifier
- 9984025433102771
Metrics
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