Origins of neonatal leptin deficiency in preterm infants

Baiba Steinbrekera; Tarah T Colaizy; Lauren K Vasilakos; Karen J Johnson; Donna A Santillan; Sarah E Haskell; Robert D Roghair

doi:10.1038/s41390-019-0359-y

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Origins of neonatal leptin deficiency in preterm infants

Journal article

Open access

Peer reviewed

Origins of neonatal leptin deficiency in preterm infants

Baiba Steinbrekera, Tarah T Colaizy, Lauren K Vasilakos, Karen J Johnson, Donna A Santillan, Sarah E Haskell and Robert D Roghair

Pediatric research, Vol.85(7), pp.1016-1023

06/2019

DOI: 10.1038/s41390-019-0359-y

PMCID: PMC6531333

PMID: 30845123

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https://doi.org/10.1038/s41390-019-0359-yView

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Abstract

Cord blood leptin increases with advancing gestation. Preterm delivery leads to premature separation from the maternal and placental leptin source predisposing infants to postnatal leptin deficiency, but this has not been fully described. Blood leptin levels were measured for infants born before 33 weeks gestation daily for the first 2 days, then weekly until 36 weeks postmenstrual age (PMA). Cord blood was obtained to provide gestational age (GA)-specific standards. Cord blood leptin levels were positively associated with GA at birth, maternal body mass index (BMI) and pregnancy weight gain (all P < 0.05). Following birth, infant leptin levels decreased rapidly (74% decrease within 48 h). The extent of this decline correlated with GA (P < 0.05). Postnatal leptin began to increase by 33-36 weeks PMA, but remained below cord blood leptin levels (P < 0.01). At 36 weeks PMA, leptin levels were influenced by infant's weight and sex (P < 0.01), with females having higher leptin levels (1213 pg/ml vs. 984, P < 0.05). Cord blood leptin is influenced by maternal weight gain and BMI, suggesting an important role for trans-placental leptin delivery. Preterm delivery leads to sustained leptin deficiency through 36 weeks PMA, with the most premature male infants facing the longest and harshest deficiency.

Leptin - blood

Prospective Studies

Infant, Premature - blood

Humans

Adult

Female

Male

Fetal Blood - metabolism

Infant, Newborn

Details

Title: Subtitle: Origins of neonatal leptin deficiency in preterm infants
Creators: Baiba Steinbrekera - Stead Family Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA
Tarah T Colaizy - Stead Family Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA
Lauren K Vasilakos - Stead Family Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA
Karen J Johnson - Stead Family Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA
Donna A Santillan - Department of Obstetrics and Gynecology, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA
Sarah E Haskell - Stead Family Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA
Robert D Roghair - Stead Family Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA. robert-roghair@uiowa.edu
Resource Type: Journal article
Publication Details: Pediatric research, Vol.85(7), pp.1016-1023
Publisher: United States
DOI: 10.1038/s41390-019-0359-y
PMID: 30845123
PMCID: PMC6531333
ISSN: 1530-0447
eISSN: 1530-0447
Grant note: R01 HL102659 / NHLBI NIH HHS UL1 TR002537 / NCATS NIH HHS
Language: English
Date published: 06/2019
Academic Unit: Critical Care; Stead Family Department of Pediatrics; Obstetrics and Gynecology; Neonatology
Record Identifier: 9983931739502771

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