Journal article
Orofacial clefting: recent insights into a complex trait
Current opinion in genetics & development, Vol.15(3), pp.270-278
06/2005
DOI: 10.1016/j.gde.2005.03.003
PMCID: PMC2442458
PMID: 15917202
Abstract
Orofacial clefts are common birth defects of multifactorial etiology. Several novel approaches have recently been applied to investigate the causes of clefts. These include examining Mendelian forms of clefting to identify genes that might also be implicated in isolated clefting, analyzing chromosomal rearrangements in which clefting is part of the resultant phenotype, studying animal models in which clefts arise either spontaneously or as a result of mutagenesis experiments, exploring how expression patterns correlate with gene function and examining the effects of gene-environment interactions. Together, these complementary strategies are providing researchers with new clues as to what mechanisms underlie orofacial clefting.
Details
- Title: Subtitle
- Orofacial clefting: recent insights into a complex trait
- Creators
- Astanand Jugessur - Department of Paediatrics, University of Iowa, Iowa City, IA 52242, USAJeffrey C Murray
- Resource Type
- Journal article
- Publication Details
- Current opinion in genetics & development, Vol.15(3), pp.270-278
- DOI
- 10.1016/j.gde.2005.03.003
- PMID
- 15917202
- PMCID
- PMC2442458
- NLM abbreviation
- Curr Opin Genet Dev
- ISSN
- 0959-437X
- eISSN
- 1879-0380
- Publisher
- England
- Grant note
- R37 DE008559 / NIDCR NIH HHS P50 DE016215 / NIDCR NIH HHS DE08559 / NIDCR NIH HHS DE16215 / NIDCR NIH HHS R01 DE008559 / NIDCR NIH HHS
- Language
- English
- Date published
- 06/2005
- Academic Unit
- Anatomy and Cell Biology; Stead Family Department of Pediatrics; Epidemiology; Pediatric Dentistry; Craniofacial Anomalies Research Center; Dental Research
- Record Identifier
- 9984025303002771
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