Journal article
Osteoarthritis-Like Changes in Bardet–Biedl Syndrome Mutant Ciliopathy Mice (Bbs1M390R/M390R): Evidence for a Role of Primary Cilia in Cartilage Homeostasis and Regulation of Inflammation
Frontiers in physiology, Vol.9, pp.708-708
06/19/2018
DOI: 10.3389/fphys.2018.00708
PMCID: PMC6018413
PMID: 29971011
Abstract
Osteoarthritis (OA) is a debilitating inflammation related disease characterized by joint pain and effusion, loss of mobility, and deformity that may result in functional joint failure and significant impact on quality of life. Once thought of as a simple “wear and tear” disease, it is now widely recognized that OA has a considerable metabolic component and is related to chronic inflammation. Defects associated with primary cilia have been shown to be cause OA-like changes in Bardet–Biedl mice. We examined the role of dysfunctional primary cilia in OA in mice through the regulation of the previously identified degradative and pro-inflammatory molecular pathways common to OA. We observed an increase in the presence of pro-inflammatory markers TGFβ-1 and HTRA1 as well as cartilage destructive protease MMP-13 but a decrease in DDR-2. We observed a morphological difference in cartilage thickness in Bbs1
M390R/M390R
mice compared to wild type (WT). We did not observe any difference in OARSI or Mankin scores between WT and
Bbs1
M390R/M390R
mice. Primary cilia appear to be involved in the upregulation of biomarkers, including pro-inflammatory markers common to OA.
Details
- Title: Subtitle
- Osteoarthritis-Like Changes in Bardet–Biedl Syndrome Mutant Ciliopathy Mice (Bbs1M390R/M390R): Evidence for a Role of Primary Cilia in Cartilage Homeostasis and Regulation of Inflammation
- Creators
- Isaac D Sheffield - Department of Physiology and Developmental Biology, Brigham Young UniversityMercedes A McGee - Department of Physiology and Developmental Biology, Brigham Young UniversitySteven J Glenn - Department of Physiology and Developmental Biology, Brigham Young UniversityDa Young Baek - Department of Physiology and Developmental Biology, Brigham Young UniversityJoshua M Coleman - Department of Physiology and Developmental Biology, Brigham Young UniversityBradley K Dorius - Department of Physiology and Developmental Biology, Brigham Young UniversityChanning Williams - Department of Physiology and Developmental Biology, Brigham Young UniversityBrandon J Rose - Department of Physiology and Developmental Biology, Brigham Young UniversityAnthony E Sanchez - Department of Physiology and Developmental Biology, Brigham Young UniversityMichael A Goodman - Department of Physiology and Developmental Biology, Brigham Young UniversityJohn M Daines - Department of Physiology and Developmental Biology, Brigham Young UniversityDennis L Eggett - Department of Physiology and Developmental Biology, Brigham Young UniversityVal C Sheffield - Departments of Pediatrics and Ophthalmology, University of IowaArminda Suli - Department of Physiology and Developmental Biology, Brigham Young UniversityDavid L Kooyman - Department of Physiology and Developmental Biology, Brigham Young University
- Resource Type
- Journal article
- Publication Details
- Frontiers in physiology, Vol.9, pp.708-708
- DOI
- 10.3389/fphys.2018.00708
- PMID
- 29971011
- PMCID
- PMC6018413
- NLM abbreviation
- Front Physiol
- ISSN
- 1664-042X
- eISSN
- 1664-042X
- Publisher
- Frontiers Media S.A
- Grant note
- Office of Research and Creative Activities, Brigham Young University
- Language
- English
- Date published
- 06/19/2018
- Academic Unit
- Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Medical Genetics and Genomics; Anesthesia; Ophthalmology and Visual Sciences
- Record Identifier
- 9984070404402771
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