Osteoarthritis: New insights. Part 1: The disease and its risk factors

David T FELSON; Reva C LAWRENCE; Maryfran SOWERS; Timothy MCALINDON; Tim D SPECTOR; A. Robin POOLE; Susan Z YANOVSKI; Gerard ATESHIAN; Leena SHARMA; Joseph A BUCKWALTER; Kenneth D BRANDT; James F FRIES; Paul A DIEPPE; Rosemarie HIRSCH; Charles G HELMICK; Joanne M JORDAN; Raynard S KINGTON; Nancy E LANE; Michael C NEVITT; Yuqing ZHANG

doi:10.7326/0003-4819-133-8-200010170-00016

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Osteoarthritis: New insights. Part 1: The disease and its risk factors

Journal article

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Osteoarthritis: New insights. Part 1: The disease and its risk factors

David T FELSON, Reva C LAWRENCE, Maryfran SOWERS, Timothy MCALINDON, Tim D SPECTOR, A. Robin POOLE, Susan Z YANOVSKI, Gerard ATESHIAN, Leena SHARMA, Joseph A BUCKWALTER, …

Annals of internal medicine, Vol.133(8), pp.635-646

2000

DOI: 10.7326/0003-4819-133-8-200010170-00016

PMID: 11033593

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Abstract

Osteoarthritis is the most common form of arthritis, affecting millions of people in the United States. It is a complex disease whose etiology bridges biomechanics and biochemistry. Evidence is growing for the role of systemic factors (such as genetics, dietary intake, estrogen use, and bone density) and of local biomechanical factors (such as muscle weakness, obesity, and joint laxity). These risk factors are particularly important in weight-bearing joints, and modifying them may present opportunities for prevention of osteoarthritis-related pain and disability. Major advances in management to reduce pain and disability are yielding a panoply of available treatments ranging from nutriceuticals to chondrocyte transplantation, new oral anti-inflammatory medications, and health education. This article is part 1 of a two-part summary of a National Institutes of Health conference. The conference brought together experts on osteoarthritis from diverse backgrounds and provided a multidisciplinary and comprehensive summary of recent advances in the prevention of osteoarthritis onset, progression, and disability. Part 1 focuses on a new understanding of what osteoarthritis is and on risk factors that predispose to disease occurrence. It concludes with a discussion of the impact of osteoarthritis on disability.

Inflammatory joint diseases

Biological and medical sciences

Medical sciences

Diseases of the osteoarticular system

Details

Title: Subtitle: Osteoarthritis: New insights. Part 1: The disease and its risk factors
Creators: David T FELSON - Boston University School of Medicine, Boston, Massachusetts, United States
Reva C LAWRENCE - Boston University School of Medicine, Boston, Massachusetts, United States
Maryfran SOWERS - Boston University School of Medicine, Boston, Massachusetts, United States
Timothy MCALINDON - Boston University School of Medicine, Boston, Massachusetts, United States
Tim D SPECTOR - Boston University School of Medicine, Boston, Massachusetts, United States
A. Robin POOLE - Boston University School of Medicine, Boston, Massachusetts, United States
Susan Z YANOVSKI - Boston University School of Medicine, Boston, Massachusetts, United States
Gerard ATESHIAN - Boston University School of Medicine, Boston, Massachusetts, United States
Leena SHARMA - Boston University School of Medicine, Boston, Massachusetts, United States
Joseph A BUCKWALTER - Boston University School of Medicine, Boston, Massachusetts, United States
Kenneth D BRANDT - Boston University School of Medicine, Boston, Massachusetts, United States
James F FRIES - Boston University School of Medicine, Boston, Massachusetts, United States
Paul A DIEPPE - Boston University School of Medicine, Boston, Massachusetts, United States
Rosemarie HIRSCH - Boston University School of Medicine, Boston, Massachusetts, United States
Charles G HELMICK - Boston University School of Medicine, Boston, Massachusetts, United States
Joanne M JORDAN - Boston University School of Medicine, Boston, Massachusetts, United States
Raynard S KINGTON - Boston University School of Medicine, Boston, Massachusetts, United States
Nancy E LANE - Boston University School of Medicine, Boston, Massachusetts, United States
Michael C NEVITT - Boston University School of Medicine, Boston, Massachusetts, United States
Yuqing ZHANG - Boston University School of Medicine, Boston, Massachusetts, United States
Resource Type: Journal article
Publication Details: Annals of internal medicine, Vol.133(8), pp.635-646
DOI: 10.7326/0003-4819-133-8-200010170-00016
PMID: 11033593
NLM abbreviation: Ann Intern Med
ISSN: 0003-4819
eISSN: 1539-3704
Publisher: American College of Physicians; Philadelphia, PA
Language: English
Date published: 2000
Academic Unit: Stead Family Department of Pediatrics; Orthopedics and Rehabilitation; Injury Prevention Research Center
Record Identifier: 9984040217802771

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