Journal article
Osteonecrosis of the jaw in patients with cancer who received zoledronic acid and bevacizumab
The Journal of the American Dental Association (1939), Vol.142(5), pp.506-513
05/01/2011
DOI: 10.14219/jada.archive.2011.0220
PMID: 21531932
Abstract
Background. The authors investigated the incidence of and risk factors for osteonecrosis of the jaw (ONJ) in patients with metastases to the bone who received the bisphosphonate agent zoledronic acid (ZOL) and chemotherapy combined with the antiangiogenic agent bevacizumab (BEV).
Methods. The authors evaluated 59 participants (34 with breast cancer and 25 with nonsmall-cell lung cancer). All of the participants received 4 milligrams of ZOL via intravenous (IV) infusion every four weeks and 15 mg per kilogram of BEV every three weeks. They conducted a dental examination in participants at baseline and every three months until the patients died or were lost to follow-up. If needed, participants received periodontal disease treatment and underwent tooth extraction before they started receiving ZOL and BEV.
Results. The median time the participants received ZOL therapy was 18.8 months (range, 3.1-28.9 months); 36 participants (61.0 percent) received ZOL therapy for more than one year. The median time participants received BEV therapy was 16.7 months (range, 2.8-29.6 months). None of the participants required dentoalveolar surgery while undergoing cancer treatment. After a median follow-up period of 19.7 months, none of the participants developed bisphosphonate-related ONJ.
Conclusions and Clinical Implications. ZOL combined with BEV did not predispose to ONJ participants with cancer that had metastasized to the bone who underwent a baseline dental examination and preventive dental measures. The study results must be considered in the context of the study's protocols and the follow-up period.
Details
- Title: Subtitle
- Osteonecrosis of the jaw in patients with cancer who received zoledronic acid and bevacizumab
- Creators
- Filippo Francini - University of SienaAlessandra Pascucci - University of SienaEdoardo Francini - University of SienaSalvatora Tindara Miano - University of SienaGianluca Bargagli - University of SienaGrazia Ruggiero - University of SienaRoberto Petrioli - University of Siena
- Resource Type
- Journal article
- Publication Details
- The Journal of the American Dental Association (1939), Vol.142(5), pp.506-513
- DOI
- 10.14219/jada.archive.2011.0220
- PMID
- 21531932
- ISSN
- 0002-8177
- eISSN
- 1943-4723
- Publisher
- Amer Dental Assoc
- Number of pages
- 8
- Language
- English
- Date published
- 05/01/2011
- Academic Unit
- Internal Medicine
- Record Identifier
- 9985221145702771
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