Journal article
Osteoporosis and fractures in HIV/hepatitis C virus coinfection: a systematic review and meta-analysis
AIDS (London), Vol.28(14), pp.2119-2131
09/10/2014
DOI: 10.1097/QAD.0000000000000363
PMCID: PMC4940983
PMID: 24977441
Abstract
Objective: There is growing evidence that fracture risk is increased in individuals with HIV and/or hepatitis C virus (HCV) infection. We systematically reviewed the literature to determine whether prevalence of osteoporosis and incidence of fracture is increased in HIV/HCV-coinfected individuals.
Design: A systematic review and meta-analysis.
Methods: A search was performed of Medline, Scopus and the Cochrane Library databases, as well as of abstracts from annual retroviral, liver and bone meetings (up to 2013) for studies with bone mineral density (BMD) or bone fracture data for HIV/HCV-coinfected individuals. Osteoporosis odds ratios (ORs) and fracture incidence rate ratios (IRRs) were estimated from studies with data on HIV-monoinfected or HIV/HCV-uninfected comparison groups.
Results: Of 15 included studies, nine reported BMD data and six reported fracture data. For HIV/HCV-coinfected, the estimated osteoporosis prevalence was 22% [95% confidence interval (95% CI) 12-31] and the crude OR for osteoporosis compared with HIV-monoinfected was 1.63 (95% CI 1.27-2.11). The pooled IRR of overall fracture risk for HIV/HCV-coinfected individuals was 1.77 (95% CI 1.44-2.18) compared with HIV-monoinfected and 2.95 (95% CI 2.17-4.01) compared with uninfected individuals. In addition to HIV/HCV-coinfection, older age, lower BMI, smoking, alcohol and substance use were significant predictors of osteoporosis and fractures across studies.
Conclusion: HIV/HCV coinfection is associated with a greater risk of osteoporosis and fracture than HIV monoinfection; fracture risk is even greater than uninfected controls. These data suggest that HIV/HCV-coinfected individuals should be targeted for fracture prevention through risk factor modification at all ages and DXA screening at age 50. (C) 2014 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins
Details
- Title: Subtitle
- Osteoporosis and fractures in HIV/hepatitis C virus coinfection: a systematic review and meta-analysis
- Creators
- Huan V. Dong - Columbia University Irving Medical CenterYamnia I. Cortes - Columbia University Irving Medical CenterStephanie Shiau - Columbia University Irving Medical CenterMichael T. Yin - Columbia University Irving Medical Center
- Resource Type
- Journal article
- Publication Details
- AIDS (London), Vol.28(14), pp.2119-2131
- DOI
- 10.1097/QAD.0000000000000363
- PMID
- 24977441
- PMCID
- PMC4940983
- NLM abbreviation
- AIDS
- ISSN
- 0269-9370
- eISSN
- 1473-5571
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 13
- Grant note
- T32 NR013454 / Training in Interdisciplinary Research to Prevent Infections R01AI095089 / NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID) T32NR013454 / NATIONAL INSTITUTE OF NURSING RESEARCH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Nursing Research (NINR) R01 AI095089 / National Institute of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Language
- English
- Date published
- 09/10/2014
- Academic Unit
- Nursing
- Record Identifier
- 9984446544302771
Metrics
4 Record Views