Osteoporosis-like bone conditions affect osseointegration of implants

John C Keller; Michelle Stewart; Melissa Roehm; Galen B Schneider

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Osteoporosis-like bone conditions affect osseointegration of implants

Journal article

Peer reviewed

Osteoporosis-like bone conditions affect osseointegration of implants

John C Keller, Michelle Stewart, Melissa Roehm and Galen B Schneider

The International journal of oral and maxillofacial implants, Vol.19(5), pp.687-694

09/2004

PMID: 15508984

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Abstract

Usage of dental implants has become common for the treatment of edentulous patients, but concerns exist over the use of implants in patients where orofacial bone loss occurs. In the present study, the osseointegration of implants in rabbits under osteoporosis-like (OP-like) conditions simulating several clinically relevant conditions is reported. Forty rabbits were divided into 4 groups of 10. Three groups of animals received daily intramuscular injections of glucocorticoids (7.5 mg/kg) for 8 weeks to induce OP-like conditions either before, simultaneous to, or after implant placement. The injections of glucocorticoids resulted in cortical thinning, irregular trabecular patterns, and impaired extracellular (ECM) matrix formation and mineralization. Although interfacial strength (8.5 +/- 1.3 MPa for the control group; 9.3 +/- 4.0 to 10.1 +/- 4.0 MPa for the experimental groups) was apparently not affected in this limited sample cohort (n = 3 per group), statistically significant decreases (P < .05) in implant-bone contact were observed in animals with OP-like conditions (49% +/- 10% for the control group; 24% +/- 16% to 42% +/- 16% for the experimental groups). Histologic features characteristic of OP-like conditions were observed in each experimental group. ECM expression also appeared to be altered and compromised in all animals with OP-like conditions, which may affect long-term biomechanical stability of the implants. OP-like conditions affect the osseointegration characteristics of implants, but long-term biomechanical stability under forces of mastication is unknown as yet.

Rabbits

Cortisone - administration & dosage

Glucocorticoids - administration & dosage

Osteoporosis - chemically induced

Calcification, Physiologic - drug effects

Integrin-Binding Sialoprotein

Cortisone - adverse effects

Extracellular Matrix - drug effects

Osseointegration - physiology

Stress, Mechanical

Male

Injections, Intramuscular

Tibia - drug effects

Tibia - pathology

Tibia - surgery

Sialoglycoproteins - drug effects

Bone Density - drug effects

Animals

Osteoporosis - pathology

Surface Properties

Dental Implants

Osteoporosis - physiopathology

Glucocorticoids - adverse effects

Disease Models, Animal

Details

Title: Subtitle: Osteoporosis-like bone conditions affect osseointegration of implants
Creators: John C Keller - Dows Institute for Dental Research, College of Dentistry, University of Iowa, Iowa City, Iowa 52242-1010, USA. john-keller@uiowa.edu
Michelle Stewart
Melissa Roehm
Galen B Schneider
Resource Type: Journal article
Publication Details: The International journal of oral and maxillofacial implants, Vol.19(5), pp.687-694
Publisher: United States
PMID: 15508984
ISSN: 0882-2786
eISSN: 1942-4434
Grant note: P60 DE 13076 / NIDCR NIH HHS T32 DE 07159 / NIDCR NIH HHS
Language: English
Date published: 09/2004
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Graduate College Admin and Gen; President; Dentistry Administration; Prosthodontics; Oral and Maxillofacial Surgery; Dental Research
Record Identifier: 9984066079702771

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