Journal article
Osteosarcoma of the Skull Base after Radiation Therapy in a Patient with McCune-Albright Syndrome: Case Report
Skull base, Vol.13(2), pp.79-084
05/2003
DOI: 10.1055/s-2003-40597
PMID: 15912163
Abstract
Sarcomas of the skull base occurring in the field of prior radiotherapy are rare; only a few have been reported in the English literature. We report a fatal osteosarcoma of the skull base arising in a patient with McCune-Albright syndrome and severe fibrous dysplasia of the skull base 22 years after radiation therapy for a pituitary adenoma. This malignancy fulfills Cahan's criteria for a radiation-induced tumor in that it arose in the radiation field of a pituitary adenoma with a latency of 22 years. The literature on radiation-induced sarcomas of the skull base is reviewed, and the predisposition of patients with isolated fibrous dysplasia or McCune-Albright syndrome to develop radiation-induced tumors is discussed. Although the risk of radiation-induced malignancy is low in the general population, special consideration should be given when contemplating the use of radiotherapy for benign disease in patients with McCune-Albright syndrome or isolated fibrous dysplasia.
Details
- Title: Subtitle
- Osteosarcoma of the Skull Base after Radiation Therapy in a Patient with McCune-Albright Syndrome: Case Report
- Creators
- Marlan R Hansen - House Ear Clinic and Institute, Los Angeles, CaliforniaJ Craig Moffat
- Resource Type
- Journal article
- Publication Details
- Skull base, Vol.13(2), pp.79-084
- Publisher
- United States
- DOI
- 10.1055/s-2003-40597
- PMID
- 15912163
- ISSN
- 1531-5010
- eISSN
- 1532-0065
- Language
- English
- Date published
- 05/2003
- Academic Unit
- Molecular Physiology and Biophysics; Neurosurgery; Otolaryngology
- Record Identifier
- 9984006335502771
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