Journal article
Outbreak of Group A Streptococcus Septicemia in Children: Clinical, Epidemiologic, and Microbiological Correlates
JAMA : the journal of the American Medical Association, Vol.266(4), pp.533-537
07/24/1991
DOI: 10.1001/jama.1991.03470040097029
PMID: 2061980
Abstract
Objective.—To determine the epidemiologic, clinical, and microbiological features of group A streptococcus septicemia in children.Design.—A descriptive series of 34 cases over an 11-year period from 1980 through 1990.Setting.—An academically affiliated tertiary-care pediatric hospital, the principal referral center for the state of Colorado and surrounding states.Participants.—Thirty-four patients with positive blood cultures for group A streptococcus (33 medical records were available).Main Outcome Measures.—Yearly incidence and clinical features of cases; microbiological features of isolated organisms.Results.—There was a significant increase (P =.01) in the incidence of group A streptococcus bacteremia over an 11-year period, with 14 (41%) of these cases occurring in 1989 and 1990. Patients had a rapidly progressing illness, usually without preceding pharyngitis. The prominent M and T types were 1 (4) and 12 (4). Eleven (73%) of the 15 strains produced pyrogenic exotoxin B that significantly correlated with production of proteinase.Conclusion.—There appears to be an increase in group A streptococcus bacteremia in children that is associated with a strain phenotype that suggests a change in organism virulence.(JAMA. 1991;266:533-537)
Details
- Title: Subtitle
- Outbreak of Group A Streptococcus Septicemia in Children: Clinical, Epidemiologic, and Microbiological Correlates
- Creators
- Mary C WheelerMartha H RoeEdward L KaplanPatrick M SchlievertJames K Todd
- Resource Type
- Journal article
- Publication Details
- JAMA : the journal of the American Medical Association, Vol.266(4), pp.533-537
- Publisher
- American Medical Association
- DOI
- 10.1001/jama.1991.03470040097029
- PMID
- 2061980
- ISSN
- 0098-7484
- eISSN
- 1538-3598
- Language
- English
- Date published
- 07/24/1991
- Academic Unit
- Microbiology and Immunology; Internal Medicine
- Record Identifier
- 9984001124202771
Metrics
17 Record Views