Journal article
Outcome of decompressive craniectomy in comparison to nonsurgical treatment in patients with malignant MCA infarction
SpringerPlus, Vol.3(1), 115
02/28/2014
DOI: 10.1186/2193-1801-3-115
PMCID: PMC3977016
PMID: 24711983
Abstract
Background
Malignant cerebral infarction is a well-recognized disease, comprising 10-15% of all cases with cerebral infarction and causing herniation and death in 80% of cases. In this study, we compare the effects of decompressive craniectomy versus conventional medical treatment on mortality rate and functional and neurological outcome in patients with malignant MCA infarction.
Methods
We performed a prospective case–control study on 60 patients younger than 80years of age suffering malignant MCA cerebral infarction. The case group underwent decompressive craniectomy in addition to routine aggressive medical care; while the control group received routine medical treatment. Patient outcome was assessed using Glasgow outcome scale and modified Rankin scale within three months of follow-up. The data were analyzed by SPSS version 16.0 software using Chi Square, One-way ANOVA and Mann–Whitney tests.
Results
There were 27 male and 33 female patients with a mean age of 60.6 years (SD = 12.3). Glasgow outcome scale score averaged 2.93 in the surgical versus 1.53 in the medical group; this difference was significant (p = 0.001). Outcome in modified Rankin scale was also significantly lower in the surgical (3.27) versus medical (5.27) group (p < 0.001). Surgery could decrease the mortality rate about 47%.
Conclusion
In this study, decompressive craniectomy could decrease mortality rate, and improve neurological and functional outcome, and decrease long-term disability in patients with malignant MCA infarction.
Details
- Title: Subtitle
- Outcome of decompressive craniectomy in comparison to nonsurgical treatment in patients with malignant MCA infarction
- Creators
- Abdolkarim Rahmanian - Shiraz University of Medical SciencesBabak Seifzadeh - Shiraz University of Medical SciencesAli Razmkon - Shiraz University of Medical SciencesPeyman Petramfar - Shiraz University of Medical SciencesJuri Kivelev - Helsinki University HospitalEhsan-Ali Alibai - Shiraz University of Medical SciencesJuha Hernesniemi - Helsinki University Hospital
- Resource Type
- Journal article
- Publication Details
- SpringerPlus, Vol.3(1), 115
- DOI
- 10.1186/2193-1801-3-115
- PMID
- 24711983
- PMCID
- PMC3977016
- NLM abbreviation
- Springerplus
- ISSN
- 2193-1801
- eISSN
- 2193-1801
- Publisher
- Springer International Publishing
- Language
- English
- Date published
- 02/28/2014
- Academic Unit
- Neurology
- Record Identifier
- 9985014709602771
Metrics
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