Outcome of primary adult penetrating keratoplasty in a Saudi Arabian population

Michael D Wagoner; El-Sayed Gonnah; Abdul-Elah Al-Towerki; King Khaled Eye Specialist Hospital Cornea Transplant Study Group

doi:10.1097/ICO.0b013e31819b00d8

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Outcome of primary adult penetrating keratoplasty in a Saudi Arabian population

Journal article

Peer reviewed

Outcome of primary adult penetrating keratoplasty in a Saudi Arabian population

Michael D Wagoner, El-Sayed Gonnah, Abdul-Elah Al-Towerki and King Khaled Eye Specialist Hospital Cornea Transplant Study Group

Cornea, Vol.28(8), pp.882-890

09/2009

DOI: 10.1097/ICO.0b013e31819b00d8

PMID: 19654527

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Abstract

To evaluate the outcome of primary adult optical penetrating keratoplasty (PKP) in a Saudi Arabian population. A retrospective review was performed of the medical records of every Saudi Arabian patient 12 years of age or older who underwent PKP for keratoconus, corneal edema, stromal scarring, or stromal dystrophy at King Khaled Eye Specialist Hospital between January 1, 1997, and December 31, 2001, and for whom a minimum of 3 months of follow-up was available. Of 910 eyes that met the inclusion criteria, there were 464 eyes with keratoconus, 188 eyes with corneal edema, 175 eyes with stromal scarring, and 83 eyes with stromal dystrophy. The 5-year survival probability was 96.1% for keratoconus, 71.1% for stromal scarring, 85.9% for stromal dystrophy, and 40.3% for corneal edema. The most significant risk factor affecting graft survival was surgical indication (P < 0.001). Among eyes with corneal edema, increasing donor age (P = 0.004) and the occurrence of one or more complications (P < 0.001) were significantly associated with an increased risk of graft failure. Overall, improvement in vision occurred in 750 (82.4%) eyes, remained the same in 97 (10.7%) eyes, and worsened in 63 (6.9%) eyes. In the Saudi Arabian population, the prognosis for graft survival and improved visual acuity is excellent for eyes with keratoconus and stromal dystrophy, good for stromal scarring, and poor for eyes with corneal edema.

Prognosis

Age Factors

Follow-Up Studies

Humans

Middle Aged

Cicatrix - surgery

Male

Corneal Stroma

Corneal Edema - surgery

Incidence

Saudi Arabia

Young Adult

Aged, 80 and over

Adult

Female

Retrospective Studies

Child

Keratoplasty, Penetrating - adverse effects

Risk Assessment

Kaplan-Meier Estimate

Graft Rejection - etiology

Graft Survival

Treatment Outcome

Postoperative Complications - epidemiology

Visual Acuity

Corneal Diseases - surgery

Keratoconus - surgery

Adolescent

Corneal Dystrophies, Hereditary - surgery

Aged

Details

Title: Subtitle: Outcome of primary adult penetrating keratoplasty in a Saudi Arabian population
Creators: Michael D Wagoner - Department of Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, Kingdom of Saudi Arabia. michael-wagoner@uiowa.edu
El-Sayed Gonnah
Abdul-Elah Al-Towerki
King Khaled Eye Specialist Hospital Cornea Transplant Study Group
Resource Type: Journal article
Publication Details: Cornea, Vol.28(8), pp.882-890
Publisher: United States
DOI: 10.1097/ICO.0b013e31819b00d8
PMID: 19654527
ISSN: 0277-3740
eISSN: 1536-4798
Language: English
Date published: 09/2009
Academic Unit: Ophthalmology and Visual Sciences
Record Identifier: 9983980057902771

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