Journal article
Outcomes after lung resection in renal transplant patients with pulmonary mucormycosis
Clinical transplantation, Vol.36(7), pp.e14689-n/a
07/01/2022
DOI: 10.1111/ctr.14689
PMID: 35477936
Abstract
Background Pulmonary mucormycosis has been associated with high mortality (reported up to 100%) in renal transplant recipients. Methods This was a retrospective analysis of renal transplant patients with pulmonary mucormycosis between April 2014 and March 2020, who underwent surgical resection of the affected lung along with liposomal amphotericin therapy. Patients with lower respiratory illness features underwent chest X-ray, high-resolution computed tomography of the chest, and those with suspicious findings underwent analysis of bronchioloalveolar fluid and transbronchial lung biopsy. Patients with histological or microbiological evidence of mucormycosis were started on liposomal Amphotericin B. Tacrolimus and mycophenolate mofetil were stopped at the time of diagnosis. Result Ten patients underwent combined management, while five patients were managed medically. At last follow up, seven out of ten patients (70%) who underwent combined management and two of the five patients (40%) who were managed medically, had a mean survival of 28.86 months (sd = 15.71, median = 25) and 14.17 months (sd = 12.21, median = 18), respectively, post-diagnosis of pulmonary mucormycosis. Conclusion Surgical resection combined with antifungals in the perioperative period and decreased immunosuppression may improve the outcomes in renal transplant patients with pulmonary mucormycosis.
Details
- Title: Subtitle
- Outcomes after lung resection in renal transplant patients with pulmonary mucormycosis
- Creators
- Abhinav Seth - Univ Iowa Hosp & Clin, Organ Transplant Ctr, Iowa City, IA USAShivakumar S. Patil - Post Graduate Institute of Medical Education and ResearchDavid Axelrod - University of IowaHarkant Singh - Post Graduate Institute of Medical Education and ResearchAshish Sharma - Post Graduate Institute of Medical Education and ResearchDeepesh Benjamin Kenwar - Post Graduate Institute of Medical Education and ResearchKim Vaiphei - Post Graduate Institute of Medical Education and ResearchMilind Mandwar - Post Graduate Institute of Medical Education and ResearchSahil Rally - Post Graduate Institute of Medical Education and ResearchSarbpreet Singh - Post Graduate Institute of Medical Education and Research
- Resource Type
- Journal article
- Publication Details
- Clinical transplantation, Vol.36(7), pp.e14689-n/a
- Publisher
- Wiley
- DOI
- 10.1111/ctr.14689
- PMID
- 35477936
- ISSN
- 0902-0063
- eISSN
- 1399-0012
- Number of pages
- 12
- Language
- English
- Date published
- 07/01/2022
- Academic Unit
- Surgery
- Record Identifier
- 9984322770002771
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