Journal article
Outcomes and Utilization of Kidneys from Deceased Donors with Acute Kidney Injury
American journal of transplantation, Vol.9(2), pp.367-373
02/01/2009
DOI: 10.1111/j.1600-6143.2008.02505.x
PMID: 19178415
Abstract
Utilization and long-term outcomes of kidneys from donors with elevated terminal serum creatinine (sCr) levels have not been reported. Using data from the Scientific Registry of Transplant Recipients from 1995 to 2007, recipient outcomes of kidneys from adult donors were evaluated stratified by standard criteria (SCD; n = 82 262) and expanded criteria (ECD; n = 16 978) donor type and by sCr <= 1.5, 1.6-2.0 and > 2.0 mg/dL. Discard rates for SCDs were ascertained. The relative risk of graft loss was similar for recipients of SCD kidneys with sCr of 1.6-2.0 and > 2.0 mg/dL, compared to <= 1.5 mg/dL. For ECD recipients, the relative risk of graft failure significantly increased with increasing sCr. Of potential SCDs, the adjusted risk of discard was higher with sCr > 2.0 mg/dL (adjusted odds ratio [AOR] 7.04, 95% confidence interval [CI] 6.5-7.6) and 1.6-2.0 mg/dL (AOR 2.7; CI 2.5-2.9) relative to sCr <= 1.5 mg/dL. Among potential SCDs, elevated terminal creatinine is a strong independent risk factor for kidney discard; yet, when kidney transplantation is performed elevated donor terminal creatinine is not a risk factor for graft loss. Further research is needed to identify safe practices for the optimal utilization of SCD kidneys from donors with acute kidney injury.
Details
- Title: Subtitle
- Outcomes and Utilization of Kidneys from Deceased Donors with Acute Kidney Injury
- Creators
- L. K. Kayler - UF Health Shands HospitalP. Garzon - UF Health Shands HospitalJ. Magliocca - UF Health Shands HospitalS. Fujita - UF Health Shands HospitalR. D. Kim - UF Health Shands HospitalA. W. Hemming - UF Health Shands HospitalR. Howard - UF Health Shands HospitalJ. D. Schold - University of Florida
- Resource Type
- Journal article
- Publication Details
- American journal of transplantation, Vol.9(2), pp.367-373
- Publisher
- Wiley
- DOI
- 10.1111/j.1600-6143.2008.02505.x
- PMID
- 19178415
- ISSN
- 1600-6135
- eISSN
- 1600-6143
- Number of pages
- 7
- Grant note
- 234-2005-370011C / Health Resources and Services Administration; United States Department of Health & Human Services; United States Health Resources & Service Administration (HRSA)
- Language
- English
- Date published
- 02/01/2009
- Academic Unit
- Surgery
- Record Identifier
- 9984322797902771
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