Journal article
Outcomes at 18 to 22 Months of Corrected Age for Infants Born at 22 to 25 Weeks of Gestation in a Center Practicing Active Management
The Journal of pediatrics, Vol.217, pp.52-58.e1
02/01/2020
DOI: 10.1016/j.jpeds.2019.08.028
PMID: 31606151
Abstract
Objective To assess the outcomes in actively managed extremely preterm infants after admission to a neonatal intensive care unit.
Study design Retrospective cohort of 255 infants born at 22-25 weeks of gestation between 2006 and 2015 at a single study institution. Infants were excluded for congenital anomaly, death in delivery room, or parental request for palliation (n = 7). Neurodevelopmental outcomes were analyzed for 169 of 214 survivors (78.9%) at 18-22 months of corrected age. Outcomes were evaluated using the Mann-Whitney U, chi(2), or Fisher exact test, where appropriate. In addition, cognitive scores of the Bayley Scales of Infant-Toddler Development (3rd edition) were assessed using generalized estimating equations.
Results Seventy infants born at 22-23 weeks of gestation (22 weeks, n = 20; 23 weeks, n = 50) and 178 infants born at 24-25 weeks of gestation (24 weeks, n = 79; 25 weeks, n = 99 infants) were included. Survival to hospital discharge of those surviving to NICU admission was 78% (55/70; 95% CI, 69%-88%) at 22-23 weeks and 89% (159/178; 95% CI, 84%-93% at 24-25 weeks; P = .02). No or mild neurodevelopmental impairment in surviving infants was 64% (29/45; 95% CI, 50%-77%) at 22-23 weeks and 76% (94/124; 95% CI, 68%-83%; P = .16) at 24-25 weeks.
Conclusions Although survival was lower in infants born at 22-23 weeks than at 24-25 weeks of gestation, the majority of survivors in both groups had positive outcomes with no or mild neurodevelopmental impairments. Further evaluation of school performance is warranted.
Details
- Title: Subtitle
- Outcomes at 18 to 22 Months of Corrected Age for Infants Born at 22 to 25 Weeks of Gestation in a Center Practicing Active Management
- Creators
- Patricia L. Watkins - University of Iowa Hospitals and ClinicsJohn M. Dagle - University of IowaEdward F. Bell - University of IowaTarah T. Colaizy - University of Iowa Hospitals and Clinics
- Resource Type
- Journal article
- Publication Details
- The Journal of pediatrics, Vol.217, pp.52-58.e1
- Publisher
- Elsevier
- DOI
- 10.1016/j.jpeds.2019.08.028
- PMID
- 31606151
- ISSN
- 0022-3476
- eISSN
- 1097-6833
- Number of pages
- 8
- Grant note
- Savvy Ferentz Research Fund
- Language
- English
- Date published
- 02/01/2020
- Academic Unit
- Stead Family Department of Pediatrics; Epidemiology; Biochemistry and Molecular Biology; Neonatology
- Record Identifier
- 9984288729602771
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