Journal article
Outcomes from the International Society of Nephrology Hemolytic Uremic Syndromes International Forum
Kidney international, Vol.106(6), pp.1038-1050
12/2024
DOI: 10.1016/j.kint.2024.09.012
PMCID: PMC12365746
PMID: 39395628
Abstract
Hemolytic uremic syndromes (HUSs) are a heterogeneous group of conditions, only some of which are mediated by complement (complement-mediated HUS). We report the outcome of the 2023 International Society of Nephrology HUS International Forum where a global panel of experts considered the current state of the art, identified areas of uncertainty, and proposed optimal solutions. Areas of uncertainty and areas for future research included the nomenclature of HUS, novel complement testing strategies, identification of biomarkers, genetic predisposition to atypical HUS, optimal dosing and withdrawal strategies for C5 inhibitors, treatment of kidney transplant recipients, disparity of access to treatment, and the next generation of complement inhibitors in complement-mediated HUS. The current rationale for optimal patient management is described.
Details
- Title: Subtitle
- Outcomes from the International Society of Nephrology Hemolytic Uremic Syndromes International Forum
- Creators
- David Kavanagh - Newcastle upon Tyne HospitalGianluigi Ardissino - Fondazione IRCCS Ca' Granda Ospedale Maggiore PoliclinicoVicky Brocklebank - Newcastle upon Tyne HospitalRomy N Bouwmeester - Radboud University NijmegenArvind Bagga - All India Institute of Medical SciencesRob ter Heine - Radboud University NijmegenSally Johnson - Newcastle upon Tyne HospitalChristoph Licht - Hospital for Sick ChildrenAlison L.T. Ma - University of Hong KongMarina Noris - Mario Negri Institute for Pharmacological ResearchManuel Praga - Research Institute Hospital 12 de OctubreEric Rondeau - Hôpital TenonAditi Sinha - All India Institute of Medical SciencesRichard J. H. Smith - University of Iowa, OtolaryngologyNeil S Sheerin - Newcastle UniversityH. Trimarchi - Hospital Británico de Buenos AiresJack F.M. Wetzels - Radboud University NijmegenMarina Vivarelli - Bambino Gesù Children's HospitalNicole C.A.J. Van de Kar - Radboud University NijmegenLarry A. Greenbaum - Emory UniversityAdrian Catalin Lungu - Institutul Clinic FundeniAleksandra Żurowska - University of GdańskAlexandra Gerogianni - Lund UniversityAnne Durkan - The University of SydneyAnne Schijvens - Radboud University Medical CenterAnne-Laure Lapeyraque - Centre Hospitalier Universitaire Sainte-JustineAnuja Java - Washington University in St. Louis School of MedicineAtif Awan - Temple Street Children's University HospitalBianca Covella - Miulli General Hospital, Acquaviva delle Fonti (Bari) ItalyBrad Dixon - University of Colorado Anschutz Medical CampusCarine El Sissy - Hôpital Européen Georges Pompidou AP-HP, Paris, Carla Nester, University of Iowa, Stead Family Children’s Hospital, Iowa CityCaroline Duinevel - Radboud University Medical CenterChristine Maville - Newcastle upon Tyne HospitalDaniel Turudic - University Hospital Centre ZagrebDiana Karpman - Lund UniversityDieter Haffner - Medizinische Hochschule HannoverElżbieta Trembecka-Dubel - Medical University of SilesiaFatih Ozaltin - Hacettepe UniversityFrancesco Emma - Bambino Gesù Children's HospitalFranz Schaefer - Heidelberg UniversityHee Gyung Kang - Seoul National University Children's HospitalHernando Trujillo - Hospital Universitario 12 De OctubreIfeoma Ulasi - University of Nigeria Teaching HospitalAlex Ekwueme - University Teaching HospitalJan Menne - KRH Klinikum Mitte - Standort Siloah, HannoverJeffrey Laurence - Weill Cornell MedicineJoaquim Calado - Universidade Nova de LisboaJohannes Hofer - Johannes Kepler University of LinzJulien Zuber - Necker Hospital, Paris Cité University, ParisJun Oh - University Medical Center Hamburg-EppendorfKarmila Abu Bakar - University of MalayaKate Smith Jackson - Newcastle UniversityDanko Milosevic - University of ZagrebGema Ariceta - Vall d'Hebron Hospital UniversitariKathleen J. Claes - Universitair Ziekenhuis LeuvenKati Kaartinen - Helsinki University HospitalKhalid Alhasan - King Saud UniversityKioa Wijnsma - Radboud University Medical CenterL.P. van den Heuvel - Radboud University Medical CenterLaura Alconcher - Hospital Interzonal General Dr. José Penna, Bahía BlancaMaria Izabel de Holanda - Hospital Geral de BonsucessoMaria Szczepańska - Medical University of SilesiaMarie-Sophie Meuleman - Centre de Recherche des CordeliersMathieu Lemaire - University of TorontoMeredith Harris - Lurie Children's HospitalMichael G. Michalopulos - Southwestern Medical CenterMichal Malina - Newcastle UniversityMihály Józsi - Eötvös Loránd UniversityNataša Stajić - Institute of Mother and Child Health Care of Serbia “Dr Vukan Čupić,” BelgradeNicole Isbel - The University of QueenslandPatrick Walsh - Newcastle UniversityPaula A. Coccia - Hospital Italiano de Buenos AiresRaja Ramachandran - Postgraduate Institute of Medical Education and ResearchRezan Topaloglu - Hacettepe UniversitySjoerd A.M.E.G. Timmermans - Maastricht UniversitySophie Chauvet - Hôpital Européen Georges-PompidouTanja Kersnik Levart - Ljubljana University Medical CentreTomas Seeman - University of OstravaVelibor Tasic - University Children’s Hospital, SkopjeVladimír Tesař - Charles UniversityWen-Chao Song - University of PennsylvaniaYuzhou Zhang - University of IowaZoltán Prohászka - Semmelweis UniversityInternational Society of Nephrology Hemolytic Uremic Syndromes International Forum Participants
- Resource Type
- Journal article
- Publication Details
- Kidney international, Vol.106(6), pp.1038-1050
- DOI
- 10.1016/j.kint.2024.09.012
- PMID
- 39395628
- PMCID
- PMC12365746
- NLM abbreviation
- Kidney Int
- ISSN
- 0085-2538
- eISSN
- 1523-1755
- Publisher
- Elsevier Inc
- Grant note
- Alexion PharmaceuticalsAstraZeneca Rare Disease
The authors thank Monica Moorthy, Charu Malik, Paolo Zavalloni, Theo Treppo, Charleigh Claire, and Ilaria Pastorino (all from the International Society of Nephrology [ISN] ) for organizational support of the ISN Atypical Hemolytic Uremic Syndromes International Forum. The authors also thank Giedre Peseckyte, the forum medical writer. This forum was supported by Alexion Pharmaceuticals and AstraZeneca Rare Disease. The authors did not receive any compensation for their work on this manuscript.
- Language
- English
- Electronic publication date
- 10/10/2024
- Date published
- 12/2024
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Molecular Physiology and Biophysics; Anatomy and Cell Biology; Nephrology, Dialysis and Transplantation; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Otolaryngology; Internal Medicine
- Record Identifier
- 9984738440102771
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