Outcomes of COVID-19 With the Mayo Clinic Model of Care and Research

John Charles O'Horo; James R. Cerhan; Elliot J. Cahn; Philippe R. Bauer; Zelalem Temesgen; Jon Ebbert; Andy Abril; Omar M. Abu Saleh; Mariam Assi; Elie F. Berbari; Dennis M. Bierle; Wendelyn Bosch; Charles D. Burger; Edison J. Cano Cevallos; Casey M. Clements; Eva M. Carmona Porquera; Natalia E. Castillo Almeida; Douglas W. Challener; Supavit Chesdachai; Isin Y. Comba; Cristina G. Corsini Campioli; Sarah J. Crane; Ala S. Dababneh; Mark J. Enzler; Hind J. Fadel; Ravindra Ganesh; Alice Gallo De Moraes; John R. Go; Joel E. Gordon; Pooja R. Gurram; Pramod K. Guru; Erika L. Halverson; Michael F. Harrison; Heather A. Heaton; Ryan Hurt; Mary J. Kasten; Augustine S. Lee; Emily R. Levy; Claudia R. Libertin; Jorge M. Mallea; William F. Marshall; Gautam Matcha; Anne M. Meehan; Pablo Moreno Franco; William G. Morice; Jennifer J. O'Brien; Richard Oeckler; Steve Ommen; Caitlin P. Oravec; Robert Orenstein; Natalie J. Ough; Raj Palraj; Bhavesh M. Patel; Vincent S. Pureza; Brian Pickering; David M. Phelan; Raymund R. Razonable; Stacey Rizza; Priya Sampathkumar; Devang K. Sanghavi; Ayan Sen; Jason L. Siegel; Kai Singbartl; Aditya S. Shah; F. N. U. Shweta; Leigh L. Speicher; Gina Suh; Hussam Tabaja; Aaron Tande; Henry H. Ting; Russell C. Tontz; James J. Vaillant; Paschalis Vergidis; Mohamed Y. Warsame; Zachary A. Yetmar; Catherine (Cate) D. Zomok; Amy W. Williams; Andrew D. Badley

doi:10.1016/j.mayocp.2020.12.006

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Outcomes of COVID-19 With the Mayo Clinic Model of Care and Research

Journal article

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Outcomes of COVID-19 With the Mayo Clinic Model of Care and Research

John Charles O'Horo, James R. Cerhan, Elliot J. Cahn, Philippe R. Bauer, Zelalem Temesgen, Jon Ebbert, Andy Abril, Omar M. Abu Saleh, Mariam Assi, Elie F. Berbari, …

Mayo Clinic proceedings, Vol.96(3), pp.601-618

03/01/2021

DOI: 10.1016/j.mayocp.2020.12.006

PMCID: PMC7831394

PMID: 33673913

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Abstract

Objective: To report the Mayo Clinic experience with coronavirus disease 2019 (COVID-19) related to patient outcomes. Methods: We conducted a retrospective chart review of patients with COVID-19 diagnosed between March 1, 2020, and July 31, 2020, at any of the Mayo Clinic sites. We abstracted pertinent comorbid conditions such as age, sex, body mass index, Charlson Comorbidity Index variables, and treatments received. Factors associated with hospitalization and mortality were assessed in univariate and multivariate models. Results: A total of 7891 patients with confirmed COVID-19 infection with research authorization on file received care across the Mayo Clinic sites during the study period. Of these, 7217 patients were adults 18 years or older who were analyzed further. A total of 897 (11.4%) patients required hospitalization, and 354 (4.9%) received care in the intensive care unit (ICU). All hospitalized patients were reviewed by a COVID-19 Treatment Review Panel, and 77.5% (695 of 897) of inpatients received a COVID-19-directed therapy. Overall mortality was 1.2% (94 of 7891), with 7.1% (64 of 897) mortality in hospitalized patients and 11.3% (40 of 354) in patients requiring ICU care. Conclusion: Mayo Clinic outcomes of patients with COVID-19 infection in the ICU, hospital, and community compare favorably with those reported nationally. This likely reflects the impact of interprofessional multidisciplinary team evaluation, effective leveraging of clinical trials and available treatments, deployment of remote monitoring tools, and maintenance of adequate operating capacity to not require surge adjustments. These best practices can help guide other health care systems with the continuing response to the COVID-19 pandemic. (C) 2020 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc.

General & Internal Medicine

Life Sciences & Biomedicine

Medicine, General & Internal

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Details

Title: Subtitle: Outcomes of COVID-19 With the Mayo Clinic Model of Care and Research
Creators: John Charles O'Horo - Mayo Clin, Div Infect Dis, 200 First St SW, Rochester, MN 55905 USA
James R. Cerhan - Mayo Clinic
Elliot J. Cahn - Mayo Clinic
Philippe R. Bauer - Mayo Clinic
Zelalem Temesgen - Mayo Clinic
Jon Ebbert - Mayo Clinic
Andy Abril - Mayo Clinic
Omar M. Abu Saleh - Mayo Clinic
Mariam Assi - Mayo Clinic
Elie F. Berbari - Mayo Clinic
Dennis M. Bierle - Mayo Clinic
Wendelyn Bosch - Mayo Clinic
Charles D. Burger - Mayo Clinic in Florida
Edison J. Cano Cevallos - Mayo Clin, Div Infect Dis, 200 First St SW, Rochester, MN 55905 USA
Casey M. Clements - Mayo Clinic
Eva M. Carmona Porquera - Mayo Clinic
Natalia E. Castillo Almeida - Mayo Clinic
Douglas W. Challener - Mayo Clinic
Supavit Chesdachai - Mayo Clinic
Isin Y. Comba - Mayo Clinic
Cristina G. Corsini Campioli - Mayo Clin, Div Infect Dis, 200 First St SW, Rochester, MN 55905 USA
Sarah J. Crane - Mayo Clinic
Ala S. Dababneh - Mayo Clinic
Mark J. Enzler - Mayo Clinic
Hind J. Fadel - Mayo Clinic
Ravindra Ganesh - Mayo Clinic
Alice Gallo De Moraes - Mayo Clinic
John R. Go - Mayo Clin, Div Infect Dis, 200 First St SW, Rochester, MN 55905 USA
Joel E. Gordon - Mayo Clinic
Pooja R. Gurram - Mayo Clinic
Pramod K. Guru - Mayo Clinic
Erika L. Halverson - Mayo Clinic
Michael F. Harrison - Mayo Clinic in Florida
Heather A. Heaton - Mayo Clinic
Ryan Hurt - Mayo Clinic
Mary J. Kasten - Mayo Clinic
Augustine S. Lee - Mayo Clinic
Emily R. Levy - Mayo Clinic in Florida
Claudia R. Libertin - Mayo Clinic
Jorge M. Mallea - Mayo Clinic
William F. Marshall - Mayo Clin, Div Infect Dis, 200 First St SW, Rochester, MN 55905 USA
Gautam Matcha - Mayo Clinic
Anne M. Meehan - Mayo Clinic
Pablo Moreno Franco - Mayo Clinic
William G. Morice - Mayo Clinic
Jennifer J. O'Brien - Mayo Clinic in Florida
Richard Oeckler - Mayo Clinic
Steve Ommen - Mayo Clinic
Caitlin P. Oravec - Mayo Clinic
Robert Orenstein - Mayo Clinic
Natalie J. Ough - Mayo Clinic
Raj Palraj - Mayo Clin, Div Infect Dis, 200 First St SW, Rochester, MN 55905 USA
Bhavesh M. Patel - Mayo Clinic
Vincent S. Pureza - Mayo Clinic
Brian Pickering - Mayo Clinic
David M. Phelan - Mayo Clinic
Raymund R. Razonable - Mayo Clinic
Stacey Rizza - Mayo Clinic
Priya Sampathkumar - Mayo Clinic
Devang K. Sanghavi - Mayo Clinic
Ayan Sen - Mayo Clinic
Jason L. Siegel - Mayo Clin, Dept Neurol, Rochester, MN 55905 USA
Kai Singbartl - Mayo Clinic
Aditya S. Shah - Mayo Clinic
F. N. U. Shweta - Mayo Clinic
Leigh L. Speicher - Mayo Clinic
Gina Suh - Mayo Clinic
Hussam Tabaja - Mayo Clinic
Aaron Tande - Mayo Clinic
Henry H. Ting - Mayo Clinic
Russell C. Tontz - Mayo Clinic
James J. Vaillant - Mayo Clinic
Paschalis Vergidis - Mayo Clinic
Mohamed Y. Warsame - Mayo Clinic
Zachary A. Yetmar - Mayo Clinic
Catherine (Cate) D. Zomok - Mayo Clin, Div Infect Dis, 200 First St SW, Rochester, MN 55905 USA
Amy W. Williams - Mayo Clinic
Andrew D. Badley - Mayo Clinic
Resource Type: Journal article
Publication Details: Mayo Clinic proceedings, Vol.96(3), pp.601-618
DOI: 10.1016/j.mayocp.2020.12.006
PMID: 33673913
PMCID: PMC7831394
NLM abbreviation: Mayo Clin Proc
ISSN: 0025-6196
eISSN: 1942-5546
Publisher: Elsevier
Number of pages: 18
Grant note: DOI: 10.13039/100004328, name: Genentech, award: AI110173, 109593, AI120698; DOI: 10.13039/100005564, name: Gilead Sciences, award: AI110173, 109593, AI120698; DOI: 10.13039/100000871, name: Mayo Clinic, award: AI110173, 109593, AI120698; DOI: 10.13039/100000060, name: National Institute of Allergy and Infectious Diseases, award: AI110173, 109593, AI120698
Language: English
Date published: 03/01/2021
Academic Unit: Epidemiology
Record Identifier: 9984368206802771

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