Journal article
Outcomes of Small for Gestational Age Infants Born at <27 Weeks' Gestation
The Journal of pediatrics, Vol.163(1), pp.55-60.e3
07/2013
DOI: 10.1016/j.jpeds.2012.12.097
PMCID: PMC3947828
PMID: 23415614
Abstract
To determine whether small for gestational age (SGA) infants born at <27 weeks gestational age (GA) are at increased risk for mortality, morbidity, and growth and neurodevelopmental impairment at 18-22 months corrected age.
This was a retrospective cohort study from National Institute of Child Health and Human Development Neonatal Research Network's Generic Database and Follow-Up Studies. Infants born at <27 weeks GA between January 2006 and July 2008 were included. SGA was defined as birth weight <10th percentile for GA based on Olsen growth curves. Infants with birth weight ≥10th percentile for GA were classified as non-SGA. Maternal and infant characteristics, neonatal outcomes, and neurodevelopmental data were compared in SGA and non-SGA infants. Neurodevelopmental impairment was defined as any of the following: cognitive score <70 on the Bayley Scales of Infant Development III, moderate or severe cerebral palsy, bilateral hearing loss (with and without amplification), or blindness (bilateral vision <20/200). Logistic regression analysis was applied to evaluate the associations between SGA status and death or neurodevelopmental impairment.
The SGA group comprised 385 infants; the non-SGA group, 2586 infants. Compared with mothers of non-SGA infants, mothers of SGA infants were more likely to have a high school education, prenatal care, cesarean delivery, pregnancy-induced hypertension, and antenatal corticosteroid exposure. Compared with non-SGA infants, SGA infants had higher mortality and were more likely to have postnatal growth failure, prolonged mechanical ventilation, and postnatal steroid use. SGA status was associated with increased risk of death or neurodevelopmental impairment (OR, 3.91; 95% CI, 2.91-5.25; P < .001).
SGA status in infants born at <27 weeks GA is associated with an increased likelihood of postnatal steroid use, mortality, growth failure, and neurodevelopmental impairment at 18-22 months corrected age.
Details
- Title: Subtitle
- Outcomes of Small for Gestational Age Infants Born at <27 Weeks' Gestation
- Creators
- Lilia C De Jesus - Department of Pediatrics, Wayne State University, Detroit, MIAthina Pappas - Department of Pediatrics, Wayne State University, Detroit, MISeetha Shankaran - Department of Pediatrics, Wayne State University, Detroit, MILei Li - Statistics and Epidemiology Unit, RTI International, Research Triangle Park, NCAbhik Das - Statistics and Epidemiology Unit, RTI International, Research Triangle Park, NCEdward F Bell - Department of Pediatrics, University of Iowa, Iowa City, IABarbara J Stoll - Department of Pediatrics, Emory University School of Medicine, Atlanta, GAAbbot R Laptook - Department of Pediatrics, Brown University, Providence, RIMichele C Walsh - Department of Pediatrics, Rainbow Babies and Children's Hospital, Case Western Reserve University, Cleveland, OHEllen C Hale - Department of Pediatrics, Emory University School of Medicine, Atlanta, GANancy S Newman - Department of Pediatrics, Rainbow Babies and Children's Hospital, Case Western Reserve University, Cleveland, OHRebecca Bara - Department of Pediatrics, Wayne State University, Detroit, MIRosemary D Higgins - Eunice Kennedy Shriver National Institute of Health and Human Development, Bethesda, MDNational Institute of Health and Human Development Neonatal Research Network
- Resource Type
- Journal article
- Publication Details
- The Journal of pediatrics, Vol.163(1), pp.55-60.e3
- DOI
- 10.1016/j.jpeds.2012.12.097
- PMID
- 23415614
- PMCID
- PMC3947828
- NLM abbreviation
- J Pediatr
- ISSN
- 0022-3476
- eISSN
- 1097-6833
- Publisher
- Elsevier BV
- Grant note
- National Center for Advancing Translational Sciences National Center for Research Resources National Institutes of Health Eunice Kennedy Shriver National Institute of Child Health and Human Development
- Language
- English
- Date published
- 07/2013
- Academic Unit
- Stead Family Department of Pediatrics; Neonatology
- Record Identifier
- 9984093320002771
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