Outcomes of Surgical Ligation after Unsuccessful Pharmacotherapy for Patent Ductus Arteriosus in Neonates Born Extremely Preterm

Dany E Weisz; Lucia Mirea; Maura H.F Resende; Linh Ly; Paige T Church; Edmond Kelly; S. Joseph Kim; Amish Jain; Patrick J McNamara; Prakesh S Shah

doi:10.1016/j.jpeds.2017.11.029

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Outcomes of Surgical Ligation after Unsuccessful Pharmacotherapy for Patent Ductus Arteriosus in Neonates Born Extremely Preterm

Journal article

Peer reviewed

Outcomes of Surgical Ligation after Unsuccessful Pharmacotherapy for Patent Ductus Arteriosus in Neonates Born Extremely Preterm

Dany E Weisz, Lucia Mirea, Maura H.F Resende, Linh Ly, Paige T Church, Edmond Kelly, S. Joseph Kim, Amish Jain, Patrick J McNamara and Prakesh S Shah

The Journal of pediatrics, Vol.195, pp.292-296.e3

04/2018

DOI: 10.1016/j.jpeds.2017.11.029

PMID: 29306492

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Abstract

A retrospective cohort study of neonates born extremely preterm with persistent patent ductus arteriosus after unsuccessful pharmacologic closure compared outcomes between 166 surgically ligated and 142 nonligated neonates. After adjustment for confounders, ligation was not associated with the composite outcome of death or neurodevelopmental impairment, neurodevelopmental impairment alone, chronic lung disease, or retinopathy of prematurity among survivors.

selection bias

confounding by indication

mortality

cerebral palsy

survival bias

neurosensory impairment

chronic lung disease

PDA

retinopathy of prematurity

nonsteroidal anti-inflammatory drug

Details

Title: Subtitle: Outcomes of Surgical Ligation after Unsuccessful Pharmacotherapy for Patent Ductus Arteriosus in Neonates Born Extremely Preterm
Creators: Dany E Weisz - Department of Newborn and Developmental Pediatrics, Sunnybrook Health Sciences Centre, Toronto, Canada
Lucia Mirea - Phoenix Children's Hospital, Phoenix, AZ
Maura H.F Resende - Department of Pediatrics, Mt. Sinai Hospital, Toronto, Canada
Linh Ly - Department of Pediatrics, University of Toronto, Toronto, Canada
Paige T Church - Department of Newborn and Developmental Pediatrics, Sunnybrook Health Sciences Centre, Toronto, Canada
Edmond Kelly - Department of Pediatrics, University of Toronto, Toronto, Canada
S. Joseph Kim - Department of Medicine, University of Toronto, Toronto, Canada
Amish Jain - Department of Pediatrics, University of Toronto, Toronto, Canada
Patrick J McNamara - Department of Pediatrics, University of Toronto, Toronto, Canada
Prakesh S Shah - Department of Pediatrics, University of Toronto, Toronto, Canada
Resource Type: Journal article
Publication Details: The Journal of pediatrics, Vol.195, pp.292-296.e3
Publisher: Elsevier Inc
DOI: 10.1016/j.jpeds.2017.11.029
PMID: 29306492
ISSN: 0022-3476
eISSN: 1097-6833
Language: English
Date published: 04/2018
Academic Unit: Stead Family Department of Pediatrics; Neonatology; Internal Medicine
Record Identifier: 9984093317202771

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