Journal article
Outcomes of adult urethroplasty with commercially available acellular matrix
Therapeutic advances in urology, Vol.10(11), pp.351-355
11/01/2018
DOI: 10.1177/1756287218790370
PMCID: PMC6180383
PMID: 30344647
Abstract
Background: Reconstruction for complex urethral strictures may necessitate grafting. Buccal mucosal graft (BMG) harvest involves additional morbidity, making off-the-shelf' options attractive. Multiple extracellular matrices (ECMs) have been used with varying degrees of success. We reviewed our experience with MatriStem (ACell, Inc., Columbia, MD, USA) to assess safety and clinical/histologic outcomes.
Methods: All patients undergoing acellular matrix-based reconstruction were included. Data regarding indications for surgery, patient demographics, subsequent procedures, clinical outcomes, and histologic analysis, when present, were collected.
Results: Eight patients undergoing urethral reconstruction with ECM were identified. All repairs were performed as staged procedures. Grafting was performed with either MatriStem alone or MatriStem and concomitant BMG. Seven patients (88%) underwent prior endoscopic intervention and five patients (71%) had failed to respond to one or multiple prior urethroplasties. Length of involved segments ranged from 2.5 to 15 cm. ECM graft placement was feasible and demonstrated excellent graft take. Among patients undergoing second-stage repairs (four of eight, 50%), 50% remained patent without the need for subsequent dilation.
Conclusions: Use of acellular matrix grafts in urethral reconstruction appears safe and feasible. Acellular matrix performs similarly to BMG with respect to graft take and contraction following staged repair. Further study is warranted.
Details
- Title: Subtitle
- Outcomes of adult urethroplasty with commercially available acellular matrix
- Creators
- Amy Marcia Pearlman - Atrium Health Wake Forest BaptistVaidehi Mujumdar - Atrium Health Wake Forest BaptistKara Elizabeth McAbee - Atrium Health Wake Forest BaptistRyan Patrick Terlecki - Atrium Health Wake Forest Baptist
- Resource Type
- Journal article
- Publication Details
- Therapeutic advances in urology, Vol.10(11), pp.351-355
- Publisher
- Sage
- DOI
- 10.1177/1756287218790370
- PMID
- 30344647
- PMCID
- PMC6180383
- ISSN
- 1756-2872
- eISSN
- 1756-2880
- Number of pages
- 5
- Language
- English
- Date published
- 11/01/2018
- Academic Unit
- Urology
- Record Identifier
- 9984320074302771
Metrics
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