Journal article
Outcomes of hypoxic respiratory failure at birth associated with previable rupture of membranes
Journal of perinatology, Vol.38(8), pp.1087-1092
08/2018
DOI: 10.1038/s41372-018-0131-x
PMID: 29785062
Abstract
To characterize clinical outcomes of infants born after previable rupture of membranes (pROM, < 23 weeks gestation and latency period ≥ 2 weeks) in relation to refractory hypoxic respiratory failure (rHRF).
pROM neonates categorized as rHRF (FiO
> 0.6 for ≥ 2 h) and treated (high frequency ventilation + inhaled nitric oxide) were compared with no rHRF group. Primary outcome was survival until discharge. Factors associated with rHRF and mortality were identified.
Overall, mortality and disability rates were 28% and 22%, respectively. Treated rHRF group (n = 32) had longer period of ROM, mortality was (31% vs. 14%; p = 0.20), with similar survival-without-disability (54% vs. 47%; p = 0.67). Higher gestational age at birth [1.57 (1.03,2.39)] and cesarean delivery [12.6 (1.22,125)] were associated with increased survival.
Birth after pROM is associated with high rates of adverse outcomes, independent of latency period. Following treatment, rHRF infants may have similar long-term outcomes as those without rHRF.
Details
- Title: Subtitle
- Outcomes of hypoxic respiratory failure at birth associated with previable rupture of membranes
- Creators
- Michelle Baczynski - Department of Respiratory Therapy, Mount Sinai Hospital, Toronto, ON, CanadaShannon Ginty - Department of Respiratory Therapy, Mount Sinai Hospital, Toronto, ON, CanadaDany Weisz - Department of Paediatrics, University of Toronto, Toronto, ON, CanadaPatrick J McNamara - Department of Physiology, University of Toronto, Toronto, ON, CanadaEdmond Kelly - Department of Paediatrics, Mount Sinai Hospital, Toronto, ON, CanadaPrakesh S Shah - Lunnenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, CanadaAmish Jain - Lunnenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada. amish.jain@sinaihealthsystem.ca
- Resource Type
- Journal article
- Publication Details
- Journal of perinatology, Vol.38(8), pp.1087-1092
- DOI
- 10.1038/s41372-018-0131-x
- PMID
- 29785062
- ISSN
- 0743-8346
- eISSN
- 1476-5543
- Language
- English
- Date published
- 08/2018
- Academic Unit
- Stead Family Department of Pediatrics; Neonatology; Internal Medicine
- Record Identifier
- 9984093325302771
Metrics
17 Record Views