Journal article
Outcomes of infants with birthweights less than 501 g compared to infants weighing 501–750 g at a center utilizing first intention high frequency jet ventilation
Frontiers in pediatrics, Vol.12, 1392079
09/09/2024
DOI: 10.3389/fped.2024.1392079
PMCID: PMC11416967
PMID: 39315359
Abstract
Background Data on clinical outcomes of infants with birthweights less than 501 g (ELBW <501 ) are limited. Objective To evaluate management strategies and clinical outcomes of ELBW <501 infants compared to infants weighing 501–750 g (ELBW 501–750 ). Methods A retrospective study of all ELBW <501 and ELBW 501–750 infants born between 2012 and 2022 at a center utilizing first intention high frequency jet ventilation was performed. Patient characteristics, clinical and outcome data were compared between the two groups. Results A total of 358 infants (92 ELBW <501 infants and 266 ELBW 501–750 ) were included. The survival rate for the ELBW <501 group was 60.9% compared to 86.5% for ELBW 501–750 . ELBW <501 infants required more frequent use of 2.0 mm endotracheal tubes, required higher FiO 2 and longer duration of mechanical ventilation. Compared to ELBW 501–750 group, the ELBW <501 group were more likely to be SGA (68.2% vs. 16.5%) and more premature (23.2 vs. 24.3 weeks) with lower survival, longer length of stay, higher incidence of ROP and lower weight at discharge but comparable rates of IVH, grade 3 BPD, discharged on supplemental oxygen, and tracheostomy. Conclusion ELBW <501 infants are at risk for significant morbidity and mortality. However, with specialized obstetric and neonatal care, survival rates of 60% are possible with respiratory outcomes comparable to ELBW 501–750 infants. However, the increased risk of severe ROP for ELBW <501 requiring either surgical or medical intervention is concerning and warrants optimal surveillance.
Details
- Title: Subtitle
- Outcomes of infants with birthweights less than 501 g compared to infants weighing 501–750 g at a center utilizing first intention high frequency jet ventilation
- Creators
- Timothy G. ElginJennifer N. BergerDinushan C. KaluarachchiJohn M. DagleBrady ThomasTarah T. ColaizyJonathan M. Klein
- Resource Type
- Journal article
- Publication Details
- Frontiers in pediatrics, Vol.12, 1392079
- Publisher
- FRONTIERS MEDIA SA; LAUSANNE
- DOI
- 10.3389/fped.2024.1392079
- PMID
- 39315359
- PMCID
- PMC11416967
- ISSN
- 2296-2360
- eISSN
- 2296-2360
- Grant note
The author(s) declare that no financial support was received for the research, authorship, and/or publication of this article.
- Language
- English
- Date published
- 09/09/2024
- Academic Unit
- Stead Family Department of Pediatrics; Epidemiology; Neonatology
- Record Identifier
- 9984702846702771
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