Journal article
Outcomes of mitral TEER in non-responders to cardiac resynchronization therapy: A systematic review and meta-analysis
Journal of cardiology, Vol.84(5), pp.317-325
11/2024
DOI: 10.1016/j.jjcc.2024.05.005
PMID: 38762190
Abstract
Secondary mitral regurgitation (MR) worsens in 10–15 % of heart failure (HF) patients receiving cardiac resynchronization therapy (CRT). Transcatheter edge-to-edge repair (TEER) with Mitra-Clip (Abbot Vascular, Santa Clara, CA, USA) therapy is associated with improved survival and decreased rates of hospitalization for HF in selected patients with secondary MR. Data on TEER outcomes in CRT-non-responders are limited. The purpose of this meta-analysis was to evaluate outcomes of mitral TEER with Mitra-Clip in CRT-non-responders.
Cochrane, Scopus, MEDLINE, and EMBASE were searched for studies discussing outcomes of Mitra-Clip in CRT non-responders. Two reviewers were independently involved in screening studies and extracting relevant data. Individual study incidence rate estimates underwent logit transformation to calculate the weighted summary proportion under the random effect model.
A total of eight reports met the inclusion criteria (439 patients). Mitra-Clip improved MR grade to ≤2+ in 83.8 % and 86.8 % of CRT non-responders at six months and one year, respectively. Symptomatic improvement (New York Heart Association class ≤II) was also found in 71 % and 78.1 % of CRT non-responders at six months and one year, respectively. The pooled overall incidence estimates of mortality at 30 days, 6 months, 1 year, and 2 years were 3.6 %, 9.2 %, 17.8 %, and 25.9 %, respectively.
TEER with Mitra-Clip in patients with significant secondary MR who do not respond to CRT was associated with MR improvement, alleviation of symptoms, and mortality rates similar to those in the COAPT trial.
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•Mitra-Clip improved MR in 83.8% and 86.3% of CRT non-responders at 6 and 12 months•Mitra-Clip led to New York Heart Association class ≤II in 71% and 78.1% of CRT non-responders at 6 and 12 months•Mortality benefit of Mitra-clip among CRT non-responders similar to COAPT study•CRT non-responders may benefit from Mitra-Clip if they meet COAPT anatomic criteria
Details
- Title: Subtitle
- Outcomes of mitral TEER in non-responders to cardiac resynchronization therapy: A systematic review and meta-analysis
- Creators
- Anan Abu Rmilah - Mayo ClinicMohammad Abdelhafez - Al-Quds UniversityAbdalla Kara Balla - Mayo Clinic in ArizonaSoban Ahmad - East Carolina UniversitySuhaib Jaber - Department of Internal Medicine, Al-Habib Hospital, Riyadh, Saudi ArabiaOmar Latif - Mayo Clinic in ArizonaIkram Haq - Mayo Clinic in ArizonaHossam Alzu'Bi - Mount Sinai HospitalAhmad Al-Abdouh - University of KentuckyMaen Assali - Hennepin County Medical CenterRamy Ghaly - University of Missouri–Kansas CityLarry Prokop - Mayo ClinicMayra E. Guerrero - Mayo Clinic in Arizona
- Resource Type
- Journal article
- Publication Details
- Journal of cardiology, Vol.84(5), pp.317-325
- DOI
- 10.1016/j.jjcc.2024.05.005
- PMID
- 38762190
- NLM abbreviation
- J Cardiol
- ISSN
- 0914-5087
- eISSN
- 1876-4738
- Publisher
- Elsevier Ltd
- Number of pages
- 9
- Language
- English
- Date published
- 11/2024
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984845249502771
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