Outcomes of renal transplantation following bone marrow transplantation

Khaled Hamawi; Margarida De Magalhaes-Silverman; J Andrew Bertolatus

doi:10.1034/j.1600-6143.2003.00015.x

Back

Outcomes of renal transplantation following bone marrow transplantation

Journal article

Open access

Peer reviewed

Outcomes of renal transplantation following bone marrow transplantation

Khaled Hamawi, Margarida De Magalhaes-Silverman and J Andrew Bertolatus

American journal of transplantation, Vol.3(3), pp.301-305

03/2003

DOI: 10.1034/j.1600-6143.2003.00015.x

PMID: 12614285

Files and links (1)

url

https://doi.org/10.1034/j.1600-6143.2003.00015.xView

Published (Version of record) Open Access

Abstract

This single center retrospective study was undertaken to determine the outcome of kidney transplantation (KT) after bone marrow transplantation (BMT) and also to determine the need for immunosuppressive therapy after KT when the BMT marrow donor is the KT donor. Kidney transplantation was performed in 10 patients with BMT nephropathy (BMTN). In six patients, the KT donor was the BMT donor; these individuals were given no long-term immunosuppression. Four other patients received KT from donors who were not the marrow donor (two living donors, two cadaveric donors). After median follow up of 34 months, no patient had an episode of acute rejection. All graft losses (n = 4) resulted from patient death. Three were because of infectious processes, including two infectious deaths in patients not on immunosuppression. Median estimated actuarial patient and graft survival (Kaplan-Meier) was 105 months. We conclude that patients with BMTN who receive KT from their marrow donor do not require immunosuppression. Whether immunosuppressive therapy is given or not, outcome appears to be determined largely by BMT-related immune dysfunction.

Humans

Middle Aged

Immune Tolerance

Male

Treatment Outcome

Bone Marrow Transplantation - methods

Kidney Transplantation - methods

Kidney Failure, Chronic - therapy

Time Factors

Adolescent

Adult

Female

Transplantation Immunology

Retrospective Studies

Transplantation Conditioning

Child

Immunosuppressive Agents - pharmacology

Details

Title: Subtitle: Outcomes of renal transplantation following bone marrow transplantation
Creators: Khaled Hamawi - Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, IA, USA. john-bertolatus@uiowa.edu
Margarida De Magalhaes-Silverman
J Andrew Bertolatus
Resource Type: Journal article
Publication Details: American journal of transplantation, Vol.3(3), pp.301-305
DOI: 10.1034/j.1600-6143.2003.00015.x
PMID: 12614285
NLM abbreviation: Am J Transplant
ISSN: 1600-6135
eISSN: 1600-6143
Language: English
Date published: 03/2003
Academic Unit: Hematology, Oncology, and Blood & Marrow Transplantation; Nephrology; Internal Medicine
Record Identifier: 9984094608202771

Metrics

14 Record Views

59 Times Cited - Web of Science