Journal article
Outcomes of treatment for hematogenous Staphylococcus aureus vertebral osteomyelitis in the MRSA ERA
The Journal of infection, Vol.57(2), pp.128-131
08/2008
DOI: 10.1016/j.jinf.2008.04.012
PMID: 18562009
Abstract
Hematogenous vertebral osteomyelitis is caused predominantly by Staphylococcus aureus. The rise in incidence of methicillin-resistant S. aureus (MRSA) has complicated the treatment of this infection. Our objective was to evaluate therapeutic outcomes for S. aureus vertebral osteomyelitis in a setting of high MRSA prevalence.
We conducted a retrospective chart review of all patients who presented with S. aureus vertebral osteomyelitis over a 7-year period at 2 tertiary care hospitals in Houston, TX, USA.
Thirty-five patients were identified who received ≥2-week course of parenteral antibiotics and had a follow-up period of at least 12 months post-therapy. MRSA was responsible for 20 (57%) cases. Mean duration of total antibiotic therapy was 61.4 days. The overall relapse rate was 14%. At 12 months post-therapy, 86% patients were cured. The one factor significantly associated with relapse was presence of undrained abscesses (p=0.04).
When the mean duration of effective antibiotic therapy was 60 days, cure rates for S. aureus vertebral osteomyelitis exceeded 80%. Drainage of all associated abscesses correlated with a significantly higher rate of cure.
Details
- Title: Subtitle
- Outcomes of treatment for hematogenous Staphylococcus aureus vertebral osteomyelitis in the MRSA ERA
- Creators
- Daniel J Livorsi - Section of Infectious Diseases, Baylor College of Medicine, One Baylor Plaza, BCM 286, N1319, Houston, TX 77030, USANaval G Daver - Section of Infectious Diseases, Baylor College of Medicine, One Baylor Plaza, BCM 286, N1319, Houston, TX 77030, USARobert L Atmar - Section of Infectious Diseases, Baylor College of Medicine, One Baylor Plaza, BCM 286, N1319, Houston, TX 77030, USASamuel A Shelburne - Section of Infectious Diseases, Baylor College of Medicine, One Baylor Plaza, BCM 286, N1319, Houston, TX 77030, USAA. Clinton White - Infectious Disease Division, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555-0435, USADaniel M Musher - Section of Infectious Diseases, Baylor College of Medicine, One Baylor Plaza, BCM 286, N1319, Houston, TX 77030, USA
- Resource Type
- Journal article
- Publication Details
- The Journal of infection, Vol.57(2), pp.128-131
- Publisher
- Elsevier Ltd
- DOI
- 10.1016/j.jinf.2008.04.012
- PMID
- 18562009
- ISSN
- 0163-4453
- eISSN
- 1532-2742
- Language
- English
- Date published
- 08/2008
- Academic Unit
- Infectious Diseases; Internal Medicine
- Record Identifier
- 9984094763102771
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