Journal article
Outcomes up to age 36 months after congenital Zika virus infection-U.S. states
Pediatric research, Vol.95(2), pp.558-565
01/2024
DOI: 10.1038/s41390-023-02787-9
PMCID: PMC10913023
PMID: 37658124
Abstract
BACKGROUND To characterize neurodevelopmental abnormalities in children up to 36 months of age with congenital Zika virus exposure. METHODS From the U.S. Zika Pregnancy and Infant Registry, a national surveillance system to monitor pregnancies with laboratory evidence of Zika virus infection, pregnancy outcomes and presence of Zika associated birth defects (ZBD) were reported among infants with available information. Neurologic sequelae and developmental delay were reported among children with ≥1 follow-up exam after 14 days of age or with ≥1 visit with development reported, respectively. RESULTS Among 2248 infants, 10.1% were born preterm, and 10.5% were small-for-gestational age. Overall, 122 (5.4%) had any ZBD; 91.8% of infants had brain abnormalities or microcephaly, 23.0% had eye abnormalities, and 14.8% had both. Of 1881 children ≥1 follow-up exam reported, neurologic sequelae were more common among children with ZBD (44.6%) vs. without ZBD (1.5%). Of children with ≥1 visit with development reported, 46.8% (51/109) of children with ZBD and 7.4% (129/1739) of children without ZBD had confirmed or possible developmental delay. CONCLUSION Understanding the prevalence of developmental delays and healthcare needs of children with congenital Zika virus exposure can inform health systems and planning to ensure services are available for affected families. IMPACT We characterize pregnancy and infant outcomes and describe neurodevelopmental abnormalities up to 36 months of age by presence of Zika associated birth defects (ZBD). Neurologic sequelae and developmental delays were common among children with ZBD. Children with ZBD had increased frequency of neurologic sequelae and developmental delay compared to children without ZBD. Longitudinal follow-up of infants with Zika virus exposure in utero is important to characterize neurodevelopmental delay not apparent in early infancy, but logistically challenging in surveillance models.
Details
- Title: Subtitle
- Outcomes up to age 36 months after congenital Zika virus infection-U.S. states
- Creators
- Varsha Neelam - National Center on Birth Defects and Developmental DisabilitiesPaul A Romitti - University of IowaKate R Woodworth - Centers for Disease Control and PreventionDaniel J Chang - Oak Ridge Associated UniversitiesNicole M Roth - National Center on Birth Defects and Developmental DisabilitiesMegan R Reynolds - National Center on Birth Defects and Developmental DisabilitiesAmanda Akosa - National Center on Birth Defects and Developmental DisabilitiesChristopher P Carr - Oak Ridge Associated UniversitiesKayla N Anderson - Centers for Disease Control and PreventionSarah B Mulkey - Children's NationalRoberta L DeBiasi - Children's NationalCara Biddle - Children's NationalEllen H Lee - New York City Department of Health and Mental HygieneAmanda L Elmore - Florida Department of HealthSarah J Scotland - Massachusetts Department of Public HealthSimiloluwa Sowunmi - California Department of Public HealthNicole D Longcore - New York State Department of HealthMuhammad Ahmed - New Jersey Department of HealthPeter H Langlois - Texas Department of State Health ServicesShea Elizabeth Browne - Virginia Department of HealthSalma Khuwaja - Houston Health and Human Services DepartmentLeah Lind - Pennsylvania Department of HealthKyoo Shim - Dallas CountyMichael Gosciminski - Rhode Island Department of HealthRachel Blumenfeld - Philadelphia Department of Public HealthShreya Khuntia - District of Columbia Department of HealthUmme-Aiman Halai - Los Angeles County Department of Public HealthAutumn Locklear - NC Department of Health and Human ServicesMary Chan - Washington State Department of HealthTeri' Willabus - Georgia Department of Public HealthJulius Tonzel - Louisiana State Department of Health and HospitalsNatalie S Marzec - Colorado Department of Public Health and EnvironmentNianest Alers Barreto - Hawaii Department of HealthConnie Sanchez - Montgomery County Department of Health and Human ServicesJane Fornoff - Illinois Department of Public HealthShelby Hale - Ohio Department of HealthAmy Nance - Utah Department of HealthLisa Iguchi - Oregon Health AuthoritySowmya N Adibhatla - Wisconsin Department of Health ServicesEmily Potts - Indiana State Department of HealthElizabeth Schiffman - Minnesota Department of HealthDevin Raman - Southern Nevada Health DistrictMorgan F McDonald - Tennessee Department of HealthBrandi Stricklin - Arkansas Department of HealthElizabeth Ludwig - Nebraska Department of Health and Human ServicesLindsay Denson - Oklahoma State Department of HealthDianna Contreras - Arizona Department of Health ServicesEmily Ferrell - Kentucky Department for Public HealthMeghan Marx - South Dakota Department of HealthKimberly Signs - Michigan Department of Health and Human ServicesAmie Cook - Kansas Department of Health and EnvironmentVinita Oberoi Leedom - South Carolina Department of Health and Environmental ControlSuzann BeauregardLucia C Orantes - Vermont Department of HealthLaura Cronquist - North Dakota Department of HealthLesley Roush - Virginia Department of HealthShana Godfred-Cato - Centers for Disease Control and PreventionSuzanne M Gilboa - National Center on Birth Defects and Developmental DisabilitiesDana Meaney-Delman - Centers for Disease Control and PreventionMargaret A Honein - Centers for Disease Control and PreventionCynthia A MooreVan T Tong - National Center on Birth Defects and Developmental Disabilities
- Resource Type
- Journal article
- Publication Details
- Pediatric research, Vol.95(2), pp.558-565
- DOI
- 10.1038/s41390-023-02787-9
- PMID
- 37658124
- PMCID
- PMC10913023
- NLM abbreviation
- Pediatr Res
- ISSN
- 0031-3998
- eISSN
- 1530-0447
- Language
- English
- Electronic publication date
- 09/01/2023
- Date published
- 01/2024
- Academic Unit
- Epidemiology; Biostatistics
- Record Identifier
- 9984461957302771
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