Journal article
Outdoor light at night and postmenopausal breast cancer risk in the NIH-AARP diet and health study
International journal of cancer, Vol.147(9), pp.2363-2372
11/01/2020
DOI: 10.1002/ijc.33016
PMID: 32488897
Abstract
Circadian disruption may play a role in breast carcinogenesis. Previous studies reported relationships between outdoor light at night (LAN) and the breast cancer risk, but their findings are mixed. There is also a need to examine LAN and breast cancer incidence according to different individual and environmental characteristics to identify subpopulations at greater risk associated with LAN exposure. We studied residential outdoor LAN estimated from satellite imagery at baseline (1996) in relation to postmenopausal breast cancer incidence over ~16 years of follow-up in 186 981 postmenopausal women including 12 318 incident postmenopausal breast cancer cases in the NIH-AARP Diet and Health Study. We used Cox proportional hazards models to estimate hazard ratios (HR) and two-sided 95% confidence intervals (CI) of the relationship between quintiles of LAN and postmenopausal breast cancer risk, overall and by hormone receptor status and cancer stage. We found that when compared to women in the lowest quintile of baseline LAN, those in the highest quintile had a 10% increase in postmenopausal breast cancer risk (HR (95% CI), 1.10 (1.02, 1.18), P-trend, .002). The association appeared to be stronger for estrogen receptor (ER) positive breast cancer (1.12 [1.02, 1.24], .007) than for ER-negative cancer (1.07 [0.85, 1.34], .66). Our findings also suggested that the relationship between LAN and breast cancer risk may differ by individual characteristics, such as smoking, alcohol drinking, sleep duration and BMI, and neighborhood environment. In conclusion, our study suggests that higher outdoor LAN exposure may be a risk factor for postmenopausal breast cancer.
Details
- Title: Subtitle
- Outdoor light at night and postmenopausal breast cancer risk in the NIH-AARP diet and health study
- Creators
- Qian Xiao - Department of Epidemiology, Human Genetics, and Environmental Sciences, The University of Texas Health Science Center at Houston, Houston, Texas, USAPeter James - Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts, USAPatrick Breheny - Department of Biostatistics, College of Public Health, University of Iowa, Iowa City, Iowa, USAPeng Jia - International Initiative on Spatial Lifecourse Epidemiology, Hong Kong, ChinaYikyung Park - Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine in St Louis, St. Louis, Missouri, USADong Zhang - Department of Health and Human physiology, College of Liberal Arts and Sciences, University of Iowa, Iowa City, Iowa, USAJared A Fisher - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland, USAMary H Ward - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland, USARena R Jones - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland, USA
- Resource Type
- Journal article
- Publication Details
- International journal of cancer, Vol.147(9), pp.2363-2372
- DOI
- 10.1002/ijc.33016
- PMID
- 32488897
- NLM abbreviation
- Int J Cancer
- ISSN
- 0020-7136
- eISSN
- 1097-0215
- Publisher
- United States
- Grant note
- R00 CA201542 / NCI NIH HHS NCI NIH HHS
- Language
- English
- Date published
- 11/01/2020
- Academic Unit
- Biostatistics; Health, Sport, and Human Physiology ; Internal Medicine
- Record Identifier
- 9984066100502771
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