Ovarian germ cell tumors

M T Cusidó; B Jordá; J Gonzalez; A García; J Xercavins

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Journal article

Ovarian germ cell tumors

M T Cusidó, B Jordá, J Gonzalez, A García and J Xercavins

European journal of gynaecological oncology, Vol.19(2), pp.130-134

1998

PMID: 9611051

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Abstract

Ovarian germ cell tumors (OGCT) are a special type of ovarian cancers due to their histology, age of presentation, prognosis and treatment. Eighteen cases of OGCT out of 313 total ovarian cancer diagnosed in Hospital Materno-Infantil Vall d'Hebredn between 1975 and 1994 are present. Mean age of the patients was 36 years. The most frequent symptom at diagnosis was abdominal bloating (44.5%). Echography was the most used diagnostic method (67%). Surgery was conservative in 44% of the cases, radical in 50% of the cases and palliative in one case. The histological types were 6 dysgerminomas and 6 malignant teratomas (33.3%), 3 malignant dermoid cysts (16.7%), 2 yolk sac tumors (11%) and 1 embryonal carcinoma. According to FIGO 1987 staging classification 14 patients were in stage I disease and 4 in stage III disease. Polychemotherapy was performed on 6 patients and postsurgical radiotherapy was performed on 2 patients. Five patients recurred in an average time of 25 months. The five-year survival rate, according to the Kaplan-Meier method, was 80% in stage I and 0% in stage III. Five-year survival rate of patients only surgically treated was 65% and in patients who underwent postsurgical co-adjuvant treatment it was 100%. Conservative surgery followed by a BEP regimen may be performed nowadays with efficacy and acceptable toxicity while conserving the fertility of these patients.

Age Distribution

Prognosis

Humans

Middle Aged

Ovarian Neoplasms - pathology

Gynecologic Surgical Procedures

Palliative Care

Cisplatin - administration & dosage

Incidence

Adult

Female

Retrospective Studies

Germinoma - therapy

Child

Etoposide - administration & dosage

Survival Rate

Combined Modality Therapy

Bleomycin - administration & dosage

Germinoma - secondary

Ovarian Neoplasms - epidemiology

Germinoma - pathology

Antineoplastic Combined Chemotherapy Protocols - therapeutic use

Spain - epidemiology

Germinoma - epidemiology

Adolescent

Ovarian Neoplasms - therapy

Aged

Neoplasm Recurrence, Local - epidemiology

Neoplasm Staging

Anthramycin - administration & dosage

Details

Title: Subtitle: Ovarian germ cell tumors
Creators: M T Cusidó - Servicio de Ginecología, Hospital Materno-Infantil de la Vall d'Hebrón, Universidad Autónoma de Barcelona, Spain
B Jordá
J Gonzalez
A García
J Xercavins
Resource Type: Journal article
Publication Details: European journal of gynaecological oncology, Vol.19(2), pp.130-134
Publisher: Italy
PMID: 9611051
ISSN: 0392-2936
Language: English
Date published: 1998
Academic Unit: Obstetrics and Gynecology
Record Identifier: 9983931746602771

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6 Times Cited - Web of Science