Journal article
Overfeeding during lactation modulates insulin and leptin signaling cascade in rats' hearts
Regulatory peptides, Vol.136(1), pp.117-121
09/11/2006
DOI: 10.1016/j.regpep.2006.05.002
PMID: 16806530
Abstract
Insulin has been described as a potential mediator of intrinsic responses to the nutritional state in the heart due to its effects on cardiac metabolism, mainly on glucose transport. It has been demonstrated that leptin can act through some components of the insulin-signaling cascade. We investigated the association between overfeeding during lactation and alterations of insulin and leptin signaling in the heart. In summary, we analyzed a feasible cross-talk between insulin and leptin through the study of some key proteins of their cascades in the heart. In order to study the effect of overfeeding on these cascades, Wistar rats were overfed through litter size reduction to only three pups. At 10 and 21 days of life, key proteins such as insulin receptor, leptin receptor, PI3-kinase, JAK2, STAT3, and GLUT4 were measured by Western blotting. Furthermore, the pups' weight and the plasma levels of insulin, leptin and glucose were determined. Overfed animals were overweight, had high insulin and leptin plasma levels, and displayed an activation of insulin and leptin cascade, leading to an increased translocation of GLUT4. We suggest that overfeeding during lactation probably alters cardiac metabolism, through the activation of a modulated cross-talk between leptin and insulin cascades.
Details
- Title: Subtitle
- Overfeeding during lactation modulates insulin and leptin signaling cascade in rats' hearts
- Creators
- Renata Oliveira PereiraAnnie Seixas Bello Moreira - Universidade do Estado do Rio de JaneiroLaís de Carvalho - Universidade do Estado do Rio de JaneiroAnibal Sanchez Moura - Universidade do Estado do Rio de Janeiro
- Resource Type
- Journal article
- Publication Details
- Regulatory peptides, Vol.136(1), pp.117-121
- Publisher
- Elsevier B.V
- DOI
- 10.1016/j.regpep.2006.05.002
- PMID
- 16806530
- ISSN
- 0167-0115
- eISSN
- 1873-1686
- Language
- English
- Date published
- 09/11/2006
- Academic Unit
- Fraternal Order of Eagles Diabetes Research Center; Endocrinology and Metabolism; Internal Medicine
- Record Identifier
- 9984420939302771
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