Overview of the findings and advances in the neurocognitive and psychosocial functioning of mild to moderate pediatric CKD: perspectives from the Chronic Kidney Disease in Children (CKiD) cohort study

Stephen R Hooper; Rebecca J Johnson; Arlene C Gerson; Marc B Lande; Shlomo Shinnar; Lyndsay A Harshman; Amy J Kogon; Matthew Matheson; Sharon Bartosh; Joann Carlson; Bradley A Warady; Susan L Furth

doi:10.1007/s00467-021-05158-w

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Overview of the findings and advances in the neurocognitive and psychosocial functioning of mild to moderate pediatric CKD: perspectives from the Chronic Kidney Disease in Children (CKiD) cohort study

Journal article

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Overview of the findings and advances in the neurocognitive and psychosocial functioning of mild to moderate pediatric CKD: perspectives from the Chronic Kidney Disease in Children (CKiD) cohort study

Stephen R Hooper, Rebecca J Johnson, Arlene C Gerson, Marc B Lande, Shlomo Shinnar, Lyndsay A Harshman, Amy J Kogon, Matthew Matheson, Sharon Bartosh, Joann Carlson, …

Pediatric nephrology (Berlin, West), Vol.37, pp.765-775

2022

DOI: 10.1007/s00467-021-05158-w

PMCID: PMC8660930

PMID: 34110493

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https://www.ncbi.nlm.nih.gov/pmc/articles/8660930View

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Abstract

The Chronic Kidney Disease in Children (CKiD) prospective cohort study was designed to address the neurocognitive, growth, cardiovascular, and disease progression of children and adolescents with mild to moderate CKD. The study has had continuous funding from NIDDK for 17 years and has contributed significant advances in pediatric CKD. The goals of this educational review are threefold: (1) to provide an overview of the neurocognitive and psychosocial studies from CKiD to date; (2) to provide best practice recommendations for those working with the neurocognitive and psychosocial aspects of pediatric CKD based on CKiD findings; and (3) to help chart future goals and directives for both research and clinical practice. This collection of 22 empirical studies has produced a number of key findings for children and adolescents with mild to moderate CKD. While various studies suggest a relatively positive presentation for this population as a whole, without evidence of significant impairment or deterioration, findings do indicate the presence of neurocognitive dysfunction, emotional-behavioral difficulties, and lower quality of life for many children with CKD. These findings support the promotion of best practices that are accompanied by additional future clinical and research initiatives with this patient population.

Details

Title: Subtitle: Overview of the findings and advances in the neurocognitive and psychosocial functioning of mild to moderate pediatric CKD: perspectives from the Chronic Kidney Disease in Children (CKiD) cohort study
Creators: Stephen R Hooper
Rebecca J Johnson
Arlene C Gerson
Marc B Lande
Shlomo Shinnar
Lyndsay A Harshman
Amy J Kogon
Matthew Matheson
Sharon Bartosh
Joann Carlson
Bradley A Warady
Susan L Furth
Resource Type: Journal article
Publication Details: Pediatric nephrology (Berlin, West), Vol.37, pp.765-775
DOI: 10.1007/s00467-021-05158-w
PMID: 34110493
PMCID: PMC8660930
NLM abbreviation: Pediatr Nephrol
ISSN: 0931-041X
eISSN: 1432-198X
Grant note: DOI: 10.13039/100000062, name: National Institute of Diabetes and Digestive and Kidney Diseases, award: U01-DK-66143
Language: English
Electronic publication date: 06/10/2021
Date published: 2022
Academic Unit: Nephrology, Dialysis and Transplantation; Stead Family Department of Pediatrics; Iowa Neuroscience Institute
Record Identifier: 9984085471902771

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