Journal article
Ovine Hemisection Model of Spinal Cord Injury
Journal of investigative surgery, Vol.34(4), pp.380-392
02/28/2021
DOI: 10.1080/08941939.2019.1639860
PMID: 31304811
Abstract
We are developing ovine models of spinal cord injury to test novel neuromodulation-based methods on spasticity. The hemisection has been reported in a number of large animal studies. Our aim is to duplicate a hemisection injury in the sheep. Our effort is explored here. Methods and Results: Three sheep underwent hemi-sectioning of the spinal cord. Quantitative gait analysis was completed both pre- and post-injury. While measurable differences in most of the 20 gait metrics were observed, relatively few were above the predicted thresholds based on error levels expected from the data. Variations in severity of injury across the three sheep were observed. Conclusions: The hemisection ovine model of spinal cord injury shows promise as a large-animal platform for developing new therapies for treating spinal cord injuries. While variability in injury severity was observed across animals, as has been observed with weight drop-based SCI models, the hemi-section approach has the advantages of procedural ease and reduced technical complexity.
Details
- Title: Subtitle
- Ovine Hemisection Model of Spinal Cord Injury
- Creators
- S Wilson - Department of Neurosurgery, University of Iowa Hospitals and ClinicsD. C Fredericks - Department of Orthopedics and Rehabilitation, University of Iowa Hospitals and ClinicsS Safayi - Graduate College, Rush UniversityN. A DeVries-Watson - Department of Orthopedics and Rehabilitation, University of Iowa Hospitals and ClinicsM. T Holland - Department of Neurosurgery, University of Iowa Hospitals and ClinicsS. J Nagel - Center for Neurological Restoration, Cleveland ClinicG. T Gillies - Department of Mechanical and Aerospace Engineering, University of VirginiaM A Howard III - Department of Neurosurgery, University of Iowa Hospitals and Clinics
- Resource Type
- Journal article
- Publication Details
- Journal of investigative surgery, Vol.34(4), pp.380-392
- DOI
- 10.1080/08941939.2019.1639860
- PMID
- 31304811
- NLM abbreviation
- J Invest Surg
- ISSN
- 0894-1939
- eISSN
- 1521-0553
- Publisher
- Taylor & Francis
- Language
- English
- Date published
- 02/28/2021
- Academic Unit
- Neurology; Iowa Technology Institute; Iowa Neuroscience Institute; Orthopedics and Rehabilitation; Craniofacial Anomalies Research Center; Neurosurgery; Otolaryngology
- Record Identifier
- 9984070962002771
Metrics
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