Journal article
Ovine Tests of a Novel Spinal Cord Neuromodulator and Dentate Ligament Fixation Method
Journal of investigative surgery, Vol.25(6), pp.366-374
12/07/2012
DOI: 10.3109/08941939.2012.677967
PMID: 23215793
Abstract
Background: To improve methods for the treatment of intractable pain, we are developing a novel intradural spinal cord stimulator that could be either attached to the dentate ligaments of the human spinal cord or fitted around the dorsal arc of the cord itself. Purpose: Our goal was to carry out the first in vivo tests of these attachment methods in an ovine model using custom-built devices and instrumentation. For eventual translational studies, we also explored methods of mimicking a human dentate ligament attachment technique in this large animal model. Methods: As a starting point, we investigated details of the gross and histological anatomy of the ovine denticulate ligaments, and compared them with their human counterpart. The gap between the dura and the spinal cord in the sheep is small; hence, the denticulate ligaments are not long enough to accommodate human-scaled attachment clips. Therefore, lateral strips of the spinal-canal dura were fashioned to serve this same device attachment function. Results: This form of dural anchoring was implemented surgically for fixation of a silicone membrane implant that had 12 electrodes, and somatosensory evoked potentials were obtained successfully when stimuli were applied to it. The dorsal arc clamping technique was also implemented. Conclusions: We demonstrated that the dural attachment method is an effective surrogate model for testing the human dentate ligament device fixation technique, and that this mode of fixation was preferable to dorsal arc attachment. The relevant surgical innovations, anatomical findings, and the preliminary electrophysiological data from a pial surface stimulator attached in this way are presented.
Details
- Title: Subtitle
- Ovine Tests of a Novel Spinal Cord Neuromodulator and Dentate Ligament Fixation Method
- Creators
- Katherine N Gibson-Corley - Department of Pathology, University of Iowa Hospitals and ClinicsHiroyuki Oya - Department of Neurosurgery, University of Iowa Hospitals and ClinicsOliver Flouty - Department of Neurosurgery, University of Iowa Hospitals and ClinicsDouglas C Fredericks - Department of Orthopaedic Surgery, University of Iowa Hospitals and ClinicsNicholas D Jeffery - Department of Veterinary Clinical Sciences, Iowa State UniversityGeorge T Gillies - Department of Mechanical and Aerospace Engineering, University of VirginiaMatthew A Howard - Department of Neurosurgery, University of Iowa Hospitals and Clinics
- Resource Type
- Journal article
- Publication Details
- Journal of investigative surgery, Vol.25(6), pp.366-374
- DOI
- 10.3109/08941939.2012.677967
- PMID
- 23215793
- NLM abbreviation
- J Invest Surg
- ISSN
- 0894-1939
- eISSN
- 1521-0553
- Publisher
- Taylor & Francis
- Language
- English
- Date published
- 12/07/2012
- Academic Unit
- Neurology; Pathology; Iowa Neuroscience Institute; Orthopedics and Rehabilitation; Craniofacial Anomalies Research Center; Neurosurgery; Otolaryngology; Ophthalmology and Visual Sciences
- Record Identifier
- 9984020797102771
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